Evidence map›Paper›PMID 31493242›Full record

ArticleMolecular neurobiology2020

Sevoflurane-Induced Dysregulation of Cation-Chloride Cotransporters NKCC1 and KCC2 in Neonatal Mouse Brain.

O H Cabrera, V Tesic, Q L Tat, S Chastain, N Quillinan, V Jevtovic-Todorovic

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Inhibitory Synaptic Influences on Developmental Motor Disorders.International journal of molecular sciences · 2023
    Review
  7. Controversies in anesthesia-induced developmental neurotoxicity.Best practice & research. Clinical anaesthesiology · 2023
    Review
  8. Review
  9. Review
  10. Review
  11. Role of GABAFrontiers in cellular neuroscience · 2022
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

O H CabreraDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, 13001 E. 17th Pl., Aurora, CO, 80045, USA. omar.cabrera@ucdenver.edu.ORCID https://orcid.org/0000-0002-9501-6720
V TesicDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, 13001 E. 17th Pl., Aurora, CO, 80045, USA.
Q L TatDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, 13001 E. 17th Pl., Aurora, CO, 80045, USA.
S ChastainDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, 13001 E. 17th Pl., Aurora, CO, 80045, USA.
N QuillinanDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, 13001 E. 17th Pl., Aurora, CO, 80045, USA.
V Jevtovic-TodorovicDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, 13001 E. 17th Pl., Aurora, CO, 80045, USA.
University of Colorado Anschutz Medical Campus · US

Funding

In vivo imaging of thalamocortical excitability during anesthesiaR01GM102525 · NIGMS · UNIVERSITY OF VIRGINIA · PI TODOROVIC, SLOBODAN M. · 2014 to 2020
$2.0M
FVMPE-RS Riser System for in vivo and in vitro imaging on anesthesia-induced developmental neurotoxicityR01GM118197 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI JEVTOVIC-TODOROVIC, VESNA · 2016 to 2019
$1.7M
Anesthesia impairs developmental axon pruning and functional neuronal networksR21HD080281 · NICHD · UNIVERSITY OF VIRGINIA · PI JEVTOVIC-TODOROVIC, VESNA · 2015 to 2016
$428k
NICHD NIH HHS R21 HD080281NIGMS NIH HHS R01 GM102525NIGMS NIH HHS R01 GM118197
6 · The paper itself

Abstract

The cation-chloride cotransporters Na

Indexed as

AnimalsAnimals, NewbornBrainCationsChloridesHippocampusK Cl- CotransportersMiceNeuronsReflex, RightingSevofluraneSolute Carrier Family 12, Member 2SymportersCationsChloridesK Cl- CotransportersSevofluraneSlc12a2 protein, mouseSolute Carrier Family 12, Member 2SymportersCation chloride cotransporterDevelopmental neurotoxicityKCC2NKCC1Sevoflurane

Identifiers

PMID31493242
PMCPMC6980440
OpenAlexW2971397584

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.