Evidence map›Paper›PMID 31493241›Full record

ArticleMolecular neurobiology2020

The Role of Free Oxygen Radicals in Lasting Hyperexcitability of Rat Subicular Neurons After Exposure to General Anesthesia During Brain Development.

Srdjan M Joksimovic, Michael R DiGruccio, Annalisa Boscolo, Vesna Jevtovic-Todorovic, Slobodan M Todorovic

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Srdjan M JoksimovicDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Mail Stop 8130, 12801 E. 17th Avenue, Rm L18-4100, Aurora, CO, 80045, USA.
Michael R DiGruccioDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Mail Stop 8130, 12801 E. 17th Avenue, Rm L18-4100, Aurora, CO, 80045, USA.
Annalisa BoscoloUOC Anaesthesia and Intensive Care, Hospital of Padua, Padua, Italy.
Vesna Jevtovic-TodorovicDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Mail Stop 8130, 12801 E. 17th Avenue, Rm L18-4100, Aurora, CO, 80045, USA.
Slobodan M TodorovicDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Mail Stop 8130, 12801 E. 17th Avenue, Rm L18-4100, Aurora, CO, 80045, USA. slobodan.todorovic@ucdenver.edu.
University of Colorado Anschutz Medical Campus · USUniversity of Padua · IT

Funding

In vivo imaging of thalamocortical excitability during anesthesiaR01GM102525 · NIGMS · UNIVERSITY OF VIRGINIA · PI TODOROVIC, SLOBODAN M. · 2014 to 2020
$2.0M
FVMPE-RS Riser System for in vivo and in vitro imaging on anesthesia-induced developmental neurotoxicityR01GM118197 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI JEVTOVIC-TODOROVIC, VESNA · 2016 to 2019
$1.7M
NIGMS NIH HHS R01 GM102525NIGMS NIH HHS R01 GM118197
6 · The paper itself

Abstract

A large number of preclinical studies have established that general anesthetics (GAs) may cause neurodevelopmental toxicity in rodents and nonhuman primates, which is followed by long-term cognitive deficits. The subiculum, the main output structure of hippocampal formation, is one of the brain regions most sensitive to exposure to GAs at the peak of synaptogenesis (i.e., postnatal day (PND) 7). We have previously shown that subicular neurons exposed to GAs produce excessive amounts of reactive oxygen species (ROS), such as hydrogen peroxide (H

Indexed as

Action PotentialsAnesthesia, GeneralAnimalsBrainFemaleHippocampusHydrogen PeroxideIsofluraneMaleNeurogenesisNeuronsRats, Sprague-DawleyReactive Oxygen SpeciesHydrogen PeroxideIsofluraneReactive Oxygen SpeciesFree oxygen radicalsLasting hyperexcitabilityRat subicular neurons

Identifiers

PMID31493241
PMCPMC7273833
OpenAlexW2971928667

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.