Evidence map›Paper›PMID 31493213›Full record

ArticleClinical oral investigations2020

Novel non-resorbable polymeric-nanostructured scaffolds for guided bone regeneration.

Manuel Toledano, José L Gutierrez-Pérez, Aida Gutierrez-Corrales, María A Serrera-Figallo, Manuel Toledano-Osorio, Juan I Rosales-Leal, Mariano Aguilar, Raquel Osorio, Daniel Torres-Lagares

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Clinical oral investigations, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Internal oblique line implants in severe mandibular atrophies.Journal of clinical and experimental dentistry · 2020
    Article
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Manuel ToledanoDental School, Colegio Máximo, Research Institute IBS, University of Granada, Campus de Cartuja s/n, 18017, Granada, Spain.
José L Gutierrez-PérezFaculty of Dentistry, Oral Surgery Section, University of Sevilla, Avicena s/n, 41009, Sevilla, Spain.
Aida Gutierrez-CorralesFaculty of Dentistry, Oral Surgery Section, University of Sevilla, Avicena s/n, 41009, Sevilla, Spain.
María A Serrera-FigalloFaculty of Dentistry, Oral Surgery Section, University of Sevilla, Avicena s/n, 41009, Sevilla, Spain.
Manuel Toledano-OsorioDental School, Colegio Máximo, Research Institute IBS, University of Granada, Campus de Cartuja s/n, 18017, Granada, Spain.
Juan I Rosales-LealDental School, Colegio Máximo, Research Institute IBS, University of Granada, Campus de Cartuja s/n, 18017, Granada, Spain.
Mariano AguilarFaculty of Medicine, Biopathology and Medicine Regenerative Institute (IBIMER, CIBM), University of Granada, Avda. de la Investigación 11, 18016, Granada, Spain.
Raquel OsorioDental School, Colegio Máximo, Research Institute IBS, University of Granada, Campus de Cartuja s/n, 18017, Granada, Spain. rosorio@ugr.es.
Daniel Torres-LagaresFaculty of Dentistry, Oral Surgery Section, University of Sevilla, Avicena s/n, 41009, Sevilla, Spain.
Universidad de Granada · ESUniversidad de Sevilla · ES

Funding

Agencia Estatal de Investigación MINECO/FEDER MAT2017-85999-P
6 · The paper itself

Abstract

objectiveThe aim of this study was to evaluate the bone-regeneration efficiency of novel polymeric nanostructured membranes and the effect of zinc, calcium, titanium, and bone morpho-protein loading on membranes, through an in vivo rabbit model. MATERIAL AND

methodsNanostructured membranes of methylmethacrylate were loaded with zinc, calcium, TiO

resultsZn-membranes (Zn-Ms) promoted the highest amount of new bone and higher bone perimeter than both unloaded and Ti-membranes (Ti-Ms). Ca-membranes (Ca-Ms) attained higher osteoid perimeter and bone perimeter than Zn-Ms. The skeleton analysis showed that Zn-Ms produced more branches and junctions at the trabecular bone than BMP-loaded membranes (BMP-Ms). Samples treated with Ti-Ms showed less bone formation and bony bridging processes. Both Zn-Ms and Ca-Ms achieved higher number of osteoblasts than the control group. BMP-Ms and Ca-Ms originated higher number of blood vessels than Ti-Ms and control group.

conclusionsZn incorporation in novel nanostructured membranes provided the highest regenerative efficiency for bone healing at the rabbit calvarial defects. CLINICAL RELEVANCE: Zn-Ms promoted osteogenesis and enhanced biological activity, as mineralized and osteoid new bone with multiple interconnected ossified trabeculae appeared in close contact with the membrane.

Indexed as

Bone RegenerationOsteogenesisAnimalsBone Morphogenetic Protein 2OsteoblastsPolymersRabbitsX-Ray MicrotomographyBone Morphogenetic Protein 2PolymersBone regenerationNon-resorbable polymerScaffoldZinc

Identifiers

PMID31493213
OpenAlexW2971834088

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.