Evidence map›Paper›PMID 31493141›Full record

ArticleBrain imaging and behavior2020

Dorsolateral prefrontal cortex hyperactivity during inhibitory control in children with ADHD in the antisaccade task.

Juan Fernandez-Ruiz, Rebecca M Hakvoort Schwerdtfeger, Nadia Alahyane, Donald C Brien, Brian C Coe, Douglas P Munoz

Abstract read
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In one paragraph

Article in Brain imaging and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Juan Fernandez-RuizDepartamento de Fisiología, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Av. Universidad 3000, Coyoacán, 04510, Ciudad de México, Mexico. jfr@unam.mx.ORCID http://orcid.org/0000-0002-4038-0904
Rebecca M Hakvoort SchwerdtfegerCentre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada.
Nadia AlahyaneCentre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada.
Donald C BrienCentre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada.
Brian C CoeCentre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada.
Douglas P MunozCentre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada.
Queen's University · CAUniversidad Nacional Autónoma de México · MX

Funding

CIHR 148418
6 · The paper itself

Abstract

Children with ADHD show significant deficits in response inhibition. A leading hypothesis suggests prefrontal hypoactivation as a possible cause, though, there is conflicting evidence. We tested the hypoactivation hypothesis by analyzing the response inhibition process within the oculomotor system. Twenty-two children diagnosed with ADHD and twenty control (CTRL) children performed the antisaccade task while undergoing an fMRI study with concurrent eye tracking. This task included a preparatory stage that cued a prosaccade (toward a stimuli) or an antisaccade (away from a stimuli) without an actual presentation of a peripheral target. This allowed testing inhibitory control without the confounding activation from an actual response. The ADHD group showed longer reaction times and more antisaccade direction errors. While both groups showed activations in saccade network areas, the ADHD showed significant hyperactivation in the dorsolateral prefrontal cortex during the preparatory stage. No other areas in the saccade network had significant activation differences between groups. Further ADHD group analysis OFF and ON stimulant medication did not show drug-related activation differences. However, they showed a significant correlation between the difference in OFF/ON preparatory activation in the precuneus, and a decrease in the number of antisaccade errors. These results do not support the hypoactivity hypothesis as an inhibitory control deficit general explanation, but instead suggest less efficiency during the inhibitory period of the antisaccade task in children. Our findings contrast with previous results in ADHD adults showing decreased preparatory antisaccade activity, suggesting a significant age-dependent maturation effect associated to the inhibitory response in the oculomotor system.

Indexed as

Attention Deficit Disorder with HyperactivityChildHumansMagnetic Resonance ImagingPrefrontal CortexReaction TimeSaccadesADHDAntisaccadesChildhoodDorsolateral prefrontal cortexMethylphenidatePrecuneus

Identifiers

PMID31493141
OpenAlexW2972273998

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.