ArticleNeurogenetics2019
Frequency of the LRRK2 G2019S mutation in South African patients with Parkinson's disease.
Article in Neurogenetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Large-scale genetic characterization of Parkinson's disease in the African and African admixed populations.Brain : a journal of neurology · 2026Article
- Comprehensive genetic screening of the South African Parkinson's disease study collection using the NeuroBooster array.medRxiv : the preprint server for health sciences · 2025Article
- Multiple sclerosis inFrontiers in neurology · 2024Article
- Genome-wide Association Identifies Novel Etiological Insights Associated with Parkinson's Disease in African and African Admixed Populations.medRxiv : the preprint server for health sciences · 2023Article
- Leveraging genetic diversity to understand monogenic Parkinson's disease's landscape in AfrAbia.American journal of neurodegenerative disease · 2023Review
- Copy Number Variation in Parkinson's Disease: An Update from Sub-Saharan Africa.Movement disorders : official journal of the Movement Disorder Society · 2021Article
- Curcumin pre-treatment may protect against mitochondrial damage inBiochemistry and biophysics reports · 2021Article
- Parkinson's Disease Research on the African Continent: Obstacles and Opportunities.Frontiers in neurology · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
G2019S in LRRK2 is the most common mutation associated with Parkinson's disease (PD). Highest frequencies are in North African Arabic (30-41%) and Ashkenazi Jewish (6-30%) populations, mostly due to founder effects. Here, we investigated the frequency of G2019S in 647 unrelated South African PD patients from different ancestral origins. It was found in only 1.2% (8/647) of patients. Notably, none of the 91 individuals of African ancestry had G2019S. It was present in 1.9% (3/154) and 1% (5/493) of early- and late-onset cases, respectively. The frequency of G2019S exhibits ethnic-specific differences and warrants further study in sub-Saharan African populations.
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