ArticleJournal of neurology2019
Deterioration of specific aspects of gait during the instrumented 6-min walk test among people with multiple sclerosis.
Article in Journal of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Characterizing gait in people with multiple sclerosis using digital data from smartphone sensors: A proposed framework.Multiple sclerosis (Houndmills, Basingstoke, England) · 2025Pooled it
- Wearable Inertial Sensors to Assess Gait during the 6-Minute Walk Test: A Systematic Review.Sensors (Basel, Switzerland) · 2020Pooled it
- The association between amyloid-beta deposition on dual-task gait performance is partially moderated by cognitive functions in healthy older adults.Scientific reports · 2025Article
- Sensors in Multiple Sclerosis.Current neurology and neuroscience reports · 2025Review
- Walk Longer! Using Wearable Inertial Sensors to Uncover Which Gait Aspects Should Be Treated to Increase Walking Endurance in People with Multiple Sclerosis.Sensors (Basel, Switzerland) · 2024Article
- Individuals With Multiple Sclerosis Exhibit More Regular Center of Mass Accelerations After Physical Therapy.Archives of rehabilitation research and clinical translation · 2024Article
- Wearable Sensor Technologies to Assess Motor Functions in People With Multiple Sclerosis: Systematic Scoping Review and Perspective.Journal of medical Internet research · 2023Article
- Gait Variability to Phenotype Common Orthopedic Gait Impairments Using Wearable Sensors.Sensors (Basel, Switzerland) · 2022Article
- Sensor-based gait analyses of the six-minute walk test identify qualitative improvement in gait parameters of people with multiple sclerosis after rehabilitation.Journal of neurology · 2022Article
- Validation of Body-Worn Sensors for Gait Analysis During a 2-min Walk Test in Children.Journal for the measurement of physical behaviour · 2022Article
- Changes in trunk and head acceleration during the 6-minute walk test and its relation to falls risk for adults with multiple sclerosis.Experimental brain research · 2022Article
- Inter-bout and intra-bout gait variability-proposed objective measures of gait deterioration during prolonged walking in spine care.Journal of spine surgery (Hong Kong) · 2022Article
- Toxic Air Pollutants and Their Effect on Multiple Sclerosis: A Review Study.Frontiers in public health · 2022Review
- Instrumented Assessment of Motor Performance Fatigability During the 6-Min Walk Test in Mildly Affected People With Multiple Sclerosis.Frontiers in neurology · 2022Article
- Article
- Towards a Mobile Gait Analysis for Patients with a Spinal Cord Injury: A Robust Algorithm Validated for Slow Walking Speeds.Sensors (Basel, Switzerland) · 2021Article
- Walking on common ground: a cross-disciplinary scoping review on the clinical utility of digital mobility outcomes.NPJ digital medicine · 2021Article
- Gait Speed Trajectory During the Six-Minute Walk Test in Multiple Sclerosis: A Measure of Walking Endurance.Frontiers in neurology · 2021Article
- The Two-Minute Walk Test in Persons with Multiple Sclerosis: Correlations of Cadence with Free-Living Walking Do Not Support Ecological Validity.International journal of environmental research and public health · 2020Article
- Gait Characteristics Harvested During a Smartphone-Based Self-Administered 2-Minute Walk Test in People with Multiple Sclerosis: Test-Retest Reliability and Minimum Detectable Change.Sensors (Basel, Switzerland) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Prolonged walking is typically impaired among people with multiple sclerosis (pwMS), however, it is unclear what the contributing factors are or how to evaluate this deterioration. We aimed to determine which gait features become worse during sustained walking and to examine the clinical correlates of gait fatigability in pwMS. Fifty-eight pwMS performed the 6-min walk test while wearing body-fixed sensors. Multiple gait domains (e.g., pace, rhythm, variability, asymmetry and complexity) were compared across each minute of the test and between mild- and moderate-disability patient groups. Associations between the decline in gait performance (i.e., gait fatigability) and patient-reported gait disability, fatigue and falls were also determined. Cadence, stride time variability, stride regularity, step regularity and gait complexity significantly deteriorated during the test. In contrast, somewhat surprisingly, gait speed and swing time asymmetry did not change. As expected, subjects with moderate disability (n = 24) walked more poorly in most gait domains compared to the mild-disability group (n = 34). Interestingly, a group × fatigue interaction effect was observed for cadence and gait complexity; these measures decreased over time in the moderate-disability group, but not in the mild group. Gait fatigability rate was significantly correlated with physical fatigue, gait disability, and fall history. These findings suggest that sustained walking affects specific aspects of gait, which can be used as markers for fatigability in MS. This effect on gait depends on the degree of disability, and may increase fall risk in pwMS. To more fully understand and monitor correlates that reflect everyday walking in pwMS, multiple domains of gait should be quantified.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.