Evidence map›Paper›PMID 31493007›Full record

ArticleSurgical and radiologic anatomy : SRA2020

On the importance of the innervation of the human cervical longitudinal ligaments at vertebral level.

Tina Stegmann, Hanno Steinke, Philipp Pieroh, Faramarz Dehghani, Anna Völker, Mathias Jakob Groll, Thomas Wolfskämpf, Michael Werner, Julia Kollan, Andreas Hinz and 1 more

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In one paragraph

Article in Surgical and radiologic anatomy : SRA, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Tina StegmannInstitute of Anatomy, University of Leipzig, Liebigstrasse 13, 04103, Leipzig, Germany.
Hanno SteinkeInstitute of Anatomy, University of Leipzig, Liebigstrasse 13, 04103, Leipzig, Germany. Steinke@medizin.uni-leipzig.de.ORCID http://orcid.org/0000-0002-7117-9330
Philipp PierohDepartment of Orthopedics, Trauma and Plastic Surgery, University of Leipzig Medical Center, Liebigstrasse 20, 04103, Leipzig, Germany.
Faramarz DehghaniDepartment of Anatomy and Cell Biology, Martin-Luther-University Halle-Wittenberg, Grosse Steinstrasse 52, 06097, Halle (Saale), Germany.
Anna VölkerDepartment of Orthopedics, Trauma and Plastic Surgery, University of Leipzig Medical Center, Liebigstrasse 20, 04103, Leipzig, Germany.
Mathias Jakob GrollDepartment of Neurosurgery, University of Leipzig Medical Center, Liebigstrasse 20, 04103, Leipzig, Germany.
Thomas WolfskämpfInstitute of Anatomy, University of Leipzig, Liebigstrasse 13, 04103, Leipzig, Germany.
Michael WernerFraunhofer Institute for Machine Tools and Forming Technology IWU, Nöthnitzer Str. 44, 01187, Dresden, Germany.
Julia KollanFaculty of Natural Science, Pharmaceutical Technology and Biopharmaceutics, Martin-Luther-University Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120, Halle (Saale), Germany.
Andreas HinzDepartment of Medical Psychology and Medical Sociology, University of Leipzig Medical Center, Philipp-Rosenthal-Str. 55, 04103, Leipzig, Germany.
Mario LeimertDepartment for Interdisciplinary Spine Surgery, AKG Klinik Hohwald GmbH, Hohwaldstrasse 40, 01844, Neustadt in Sachsen, Germany.
Leipzig University · DEMartin Luther University Halle-Wittenberg · DEFraunhofer Institute for Machine Tools and Forming Technology · DELeipzig University of Applied Sciences · DE

Funding

Sächsisches Staatsministerium für Wissenschaft und Kunst 100096796
6 · The paper itself

Abstract

purposeIn our aging society, the prevalence of degenerative spinal diseases rose drastically within the last years. However, up till now, the origin of cervical pain is incompletely understood. While animal and small cadaver studies indicate that a complex system of sensory and nociceptive nerve fibers in the anterior (ALL) and posterior longitudinal ligament (PLL) at the level of the intervertebral disc might be involved, there is a lack of data exploring whether such a network exists and is equally distributed within the cervical vertebrae (VB). We, therefore, aimed to investigate the spatial distribution of the mentioned nerve networks in human tissue.

methodsWe performed macroscopic (Sihler staining, Spalteholz technique, and Plastination) and microscopic (immunohistochemistry for PGP 9.5 and CGRP) studies to characterize spatial differences in sensory and nociceptive innervation patterns. Therefore, 23 human body donors were dissected from level C3-C6.

resultsWe could show that there is a focal increase in sensory and nociceptive nerve fibers at the level of C4 and C5 for both ALL and PLL, while we observed less nerve fiber density at the level of C3 and C6. An anatomical vicinity between nerve and vessels was observed.

conclusionTo our knowledge, these findings for the first time report spatial differences in sensory and nociceptive nerve fibers in the human cervical spine at VB level. The interconnection between nerves and vessels supports the importance of the perivascular plexus. These findings might be of special interest for clinical practice as many patients suffer from pain after cervical spine surgery.

Indexed as

AgedAged, 80 and overCadaverCervical VertebraeFemaleHumansIntervertebral Disc DegenerationLongitudinal LigamentsMaleNeckNeck PainNerve FibersNociceptionAutonomic nerve systemCervical anterior longitudinal ligamentCervical posterior longitudinal ligamentCGRPPainPGP 9.5

Identifiers

PMID31493007
OpenAlexW2971505165

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.