ReviewNature reviews. Neuroscience2019
The brain's default network: updated anatomy, physiology and evolving insights.
Review in Nature reviews. Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 555 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
555 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- External Source Monitoring and Reality Monitoring: Meta-Analysis of fMRI Studies.Human brain mapping · 2026Pooled it
- Multimodal abnormalities of brain function in chronic low back pain: a systematic review and meta-analysis of neuroimaging studies.Frontiers in neuroscience · 2025Pooled it
- A meta-analysis of cognitive flexibility in aging: Perspective from functional network and lateralization.Human brain mapping · 2024Pooled it
- Inhibitory Control Training Improves Cold but Not Warm Cognition in Typically Developing Preschoolers.Child psychiatry and human development · 2026Trial
- The effect of intranasal oxytocin on the neuropsychological substrates of intergroup categorization.Brain imaging and behavior · 2026Trial
- Real-time fMRI neurofeedback modulates auditory cortex activity and connectivity in schizophrenia patients with auditory hallucinations: A controlled study.Psychiatry research. Neuroimaging · 2025Trial
- Cardiovascular risk factors are associated with lower posterior-medial network functional connectivity in older adults.Alzheimer's research & therapy · 2025Trial
- Medial parietal alpha-frequency transcranial alternating current stimulation for chronic insomnia: a randomized sham-controlled trial.Psychological medicine · 2025Trial
- Using mindfulness-based intervention to promote executive function in young children: a multivariable and multiscale sample entropy study.Cerebral cortex (New York, N.Y. : 1991) · 2024Trial
- Graph analysis uncovers an opposing impact of methylphenidate on connectivity patterns within default mode network sub-divisions.Behavioral and brain functions : BBF · 2024Trial
- Functional connectivity correlates of sequence memory decline in healthy older adults.GeroScience · 2026Article
- Family medicine meets participation science: Case for including patient groups in family practice.Canadian family physician Medecin de famille canadien · 2026Article
- Article
- Medial temporal default mode network selectively encodes autobiographical visual imagery.Science advances · 2026Article
- Altered default mode, limbic, and dorsal attention network connectivity after negative mood induction in problematic internet use.Brain imaging and behavior · 2026Article
- Retinotopic coding organizes the interaction between internally and externally oriented brain networks.eLife · 2026Article
- Article
- Neural integrator and orchestrator communities shape spontaneous signaling in the human brain.PNAS nexus · 2026Article
- Adolescent exposure to the psychedelic 25C-NBOMe in rats induces lasting competitive avoidance through disrupted hippocampal-prefrontal synchrony.Nature neuroscience · 2026Article
- Neural Circuit Mechanisms of Disorders of Consciousness and Potential Therapeutic Targets of Brain Stimulation.CNS neuroscience & therapeutics · 2026Review
495 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Discoveries over the past two decades demonstrate that regions distributed throughout the association cortex, often called the default network, are suppressed during tasks that demand external attention and are active during remembering, envisioning the future and making social inferences. This Review describes progress in understanding the organization and function of networks embedded within these association regions. Detailed high-resolution analyses of single individuals suggest that the default network is not a single network, as historically described, but instead comprises multiple interwoven networks. The multiple networks share a common organizational motif (also evident in marmoset and macaque anatomical circuits) that might support a general class of processing function dependent on internally constructed rather than externally constrained representations, with each separate interwoven network specialized for a distinct processing domain. Direct neuronal recordings in humans and monkeys reveal evidence for competitive relationships between the internally and externally oriented networks. Findings from rodent studies suggest that the thalamus might be essential to controlling which networks are engaged through specialized thalamic reticular neurons, including antagonistic subpopulations. These association networks (and presumably thalamocortical circuits) are expanded in humans and might be particularly vulnerable to dysregulation implicated in mental illness.
Indexed as
Identifiers
31492945What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.