Evidence map›Paper›PMID 31492920›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2019

Risk of development of treated retinopathy of prematurity in very low birth weight infants.

Samantha Gonski, Susan R Hupp, C Michael Cotten, Reese H Clark, Matthew Laughon, Kevin Watt, Christoph P Hornik, Karan Kumar, P Brian Smith, Rachel G Greenberg

Abstract readMulticenter Study
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Samantha GonskiNorth Carolina School of Science and Mathematics, Durham, NC, USA.
Susan R HuppDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
C Michael CottenDepartment of Pediatrics, Duke University, Durham, NC, USA.
Reese H ClarkPediatrix-Obstetrix Center for Research and Education, Sunrise, FL, USA.
Matthew LaughonSchool of Medicine, Division of Neonatal-Perinatal Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Kevin WattDepartment of Pediatrics, Duke University, Durham, NC, USA.
Christoph P HornikDepartment of Pediatrics, Duke University, Durham, NC, USA.
Karan KumarDepartment of Pediatrics, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0001-9196-6350
P Brian SmithDepartment of Pediatrics, Duke University, Durham, NC, USA.
Rachel G GreenbergDepartment of Pediatrics, Duke University, Durham, NC, USA. rachel.greenberg@duke.edu.ORCID http://orcid.org/0000-0003-4156-8543

Funding

Physiologically-Based Pharmacokinetic Approach to Determine Dosing on Extracorporeal Life SupportR01HD097775 · NICHD · UNIVERSITY OF UTAH · PI WATT, KEVIN M · 2019 to 2023
$2.7M
Mentorship of Early-Career Clinicians in Bronchopulmonary Dysplasia Drug TherapiesK24HL143283 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LAUGHON, MATTHEW · 2019 to 2023
$613k
NHLBI NIH HHS K24 HL143283NICHD NIH HHS HHSN275201000003CNICHD NIH HHS HHSN275201000003INICHD NIH HHS HHSN275201800003INICHD NIH HHS R01 HD097775
6 · The paper itself

Abstract

objectiveQuantify the risk of treatment for retinopathy of prematurity (ROP) among infants meeting current U.S. screening guidelines. STUDY

designAmong infants ≤1500 g birth weight or ≤30 weeks gestation screened for ROP from 2006-2015, we developed a risk prediction model to identify infants treated for ROP. We applied our model to a separate infant cohort discharged in 2016.

resultSeventy-five thousand eight hundred and twenty one infants met inclusion criteria; 2306 (3%) were treated for ROP. Infants with several risk factor combinations (no ventilator support or oxygen on postnatal day 28, no history of necrotizing enterocolitis, and no intraventricular hemorrhage) were at low risk of ROP. Applied to 6127 infants discharged in 2016, our model had 97.9% sensitivity, 63.3% specificity, positive predictive value of 4.0%, and negative predictive value of 99.9%.

conclusionLarge numbers of infants at low risk of developing ROP are required to undergo screening. Refining current ROP guidelines may reduce unnecessary examinations.

Indexed as

Birth WeightInfant, Very Low Birth WeightWeight GainCohort StudiesFemaleGestational AgeHumansInfant, NewbornInfant, PrematureLogistic ModelsMaleNeonatal ScreeningRetinopathy of PrematurityRisk AssessmentRisk FactorsSensitivity and Specificity

Identifiers

PMID31492920
PMCPMC8742217

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.