ArticleScientific reports2019
Varying crosslinking motifs drive the mesoscale mechanics of actin-microtubule composites.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Dissecting cytoskeletal crosstalk through reconstituted actin-microtubule systems.Molecular biology of the cell · 2026Review
- BARCODE: high throughput screening and analysis of soft active materials.Nature communications · 2025Article
- Kinesin-Driven De-Mixing of Cytoskeleton Composites Drives Emergent Mechanical Properties.Macromolecular rapid communications · 2025Article
- Scale-dependent interactions enable emergent microrheological stress response of actin-vimentin composites.Soft matter · 2024Article
- How cytoskeletal crosstalk makes cells move: Bridging cell-free and cell studies.Biophysics reviews · 2024Review
- Kinesin and myosin motors compete to drive rich multiphase dynamics in programmable cytoskeletal composites.PNAS nexus · 2023Article
- Nonlinear Microscale Mechanics of Actin Networks Governed by Coupling of Filament Crosslinking and Stabilization.Polymers · 2022Article
- Optical-Tweezers-integrating-Differential-Dynamic-Microscopy maps the spatiotemporal propagation of nonlinear strains in polymer blends and composites.Nature communications · 2022Article
- Multiscale architecture: Mechanics of composite cytoskeletal networks.Biophysics reviews · 2022Review
- Reconstituting and Characterizing Actin-Microtubule Composites with Tunable Motor-Driven Dynamics and Mechanics.Journal of visualized experiments : JoVE · 2022Article
- Motor-driven advection competes with crowding to drive spatiotemporally heterogeneous transport in cytoskeleton composites.Frontiers in physics · 2022Article
- DNA Conformation Dictates Strength and Flocculation in DNA-Microtubule Composites.ACS macro letters · 2021Article
- Active cytoskeletal composites display emergent tunable contractility and restructuring.Soft matter · 2021Article
- Motor-Driven Restructuring of Cytoskeleton Composites Leads to Tunable Time-Varying Elasticity.ACS macro letters · 2021Article
- Modeling links softening of myelin and spectrin scaffolds of axons after a concussion to increased vulnerability to repeated injuries.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Cell nucleus as a microrheological probe to study the rheology of the cytoskeleton.Biophysical journal · 2021Article
- Subtle changes in crosslinking drive diverse anomalous transport characteristics in actin-microtubule networks.Soft matter · 2021Article
- Myosin-driven actin-microtubule networks exhibit self-organized contractile dynamics.Science advances · 2021Article
- New twists in actin-microtubule interactions.Molecular biology of the cell · 2021Review
- Triggering Cation-Induced Contraction of Cytoskeleton Networks via Microfluidics.Frontiers in physics · 2020Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
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Abstract
The cytoskeleton precisely tunes its mechanics by altering interactions between semiflexible actin filaments, rigid microtubules, and crosslinking proteins. We use optical tweezers microrheology and confocal microscopy to characterize how varying crosslinking motifs impact the mesoscale mechanics and mobility of actin-microtubule composites. We show that, upon subtle changes in crosslinking patterns, composites can exhibit two distinct classes of force response - primarily elastic versus more viscous. For example, a composite in which actin and microtubules are crosslinked to each other but not to themselves is markedly more elastic than one in which both filaments are independently crosslinked. Notably, this distinction only emerges at mesoscopic scales in response to nonlinear forcing, whereas varying crosslinking motifs have little impact on the microscale mechanics and mobility. Our unexpected scale-dependent results not only inform the physics underlying key cytoskeleton processes and structures, but, more generally, provide valuable perspective to materials engineering endeavors focused on polymer composites.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.