ArticleNature communications2019
Pupil-linked phasic arousal evoked by violation but not emergence of regularity within rapid sound sequences.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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Who cites it
46 citing papers in PubMed, 105 citations in OpenAlex.
- Early intervention increases reactive joint attention in autistic preschoolers with arousal regulation as mediator.European child & adolescent psychiatry · 2025Trial
- Fluctuations in arousal reflect latent state transitions that facilitate behavioural optimization.Nature human behaviour · 2026Article
- Modality-general sensitivity of pupil responses to regularity violations.Cognitive, affective & behavioral neuroscience · 2026Article
- Salient features of task-irrelevant continuous speech distort subjective time.Journal of experimental psychology. General · 2026Article
- Locus-Coeruleus Norepinephrine Functioning as a Predictor of Childhood Mental Health (LOCUS-MENTAL): Protocol for a Longitudinal Study.JMIR research protocols · 2026Article
- Pupil-linked arousal heterogeneously modulates cell-type-specific sensory processing.Science advances · 2026Article
- Non-linear relationships between auditory mismatch responses and the inharmonicity of complex sounds.Scientific reports · 2026Article
- The Interplay of Bottom-Up Arousal and Attentional Capture during Auditory Scene Analysis: Evidence from Ocular Dynamics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- The Contribution of the Locus Ceruleus-Norepinephrine System to the Coupling between Pupil-Linked Arousal and Cortical State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Article
- Locus coeruleus tonic upregulation increases selectivity to inconspicuous auditory information in autistic compared to non-autistic individuals: a combined pupillometry and electroencephalography study.Molecular autism · 2025Article
- Boundaries in the eyes: Measure event segmentation during naturalistic video watching using eye tracking.Behavior research methods · 2025Article
- Arousal state fluctuations are a source of internal noise underlying age-related declines in speech intelligibility.bioRxiv : the preprint server for biology · 2025Article
- Pupillometric signature of implicit learning of statistical regularities.Current biology : CB · 2025Article
- Distortion of overlapping memories relates to arousal and anxiety.Cognitive, affective & behavioral neuroscience · 2025Article
- Pupil responds spontaneously to visuospatial regularity.Journal of vision · 2025Article
- Toward a computational role for locus coeruleus/norepinephrine arousal systems.Current opinion in behavioral sciences · 2024Article
- Neural Mechanisms Determining the Duration of Task-free, Self-paced Visual Perception.Journal of cognitive neuroscience · 2024Article
- Pupil diameter as an indicator of sound pair familiarity after statistically structured auditory sequence.Scientific reports · 2024Article
- Changes in pupil size track self-control failure.Experimental brain research · 2024Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
The ability to track the statistics of our surroundings is a key computational challenge. A prominent theory proposes that the brain monitors for unexpected uncertainty - events which deviate substantially from model predictions, indicating model failure. Norepinephrine is thought to play a key role in this process by serving as an interrupt signal, initiating model-resetting. However, evidence is from paradigms where participants actively monitored stimulus statistics. To determine whether Norepinephrine routinely reports the statistical structure of our surroundings, even when not behaviourally relevant, we used rapid tone-pip sequences that contained salient pattern-changes associated with abrupt structural violations vs. emergence of regular structure. Phasic pupil dilations (PDR) were monitored to assess Norepinephrine. We reveal a remarkable specificity: When not behaviourally relevant, only abrupt structural violations evoke a PDR. The results demonstrate that Norepinephrine tracks unexpected uncertainty on rapid time scales relevant to sensory signals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.