Evidence map›Paper›PMID 31492853›Full record

ArticleNature communications2019

Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration.

Bojana Lucic, Heng-Chang Chen, Maja Kuzman, Eduard Zorita, Julia Wegner, Vera Minneker, Wei Wang, Raffaele Fronza, Stefanie Laufs, Manfred Schmidt and 5 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 74 papers.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed
8.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 120 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. HIV reservoirs in lymphomagenesis: hidden driver in the era of viral suppression?Microbiology and molecular biology reviews : MMBR · 2025
    Review
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  10. Article
  11. Review
  12. Article
  13. Review
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  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 5 countries.

Bojana Lucic *Department of Infectious Diseases, Integrative Virology, Heidelberg University Hospital and German Center for Infection Research, Heidelberg, Germany.
Heng-Chang Chen *Genome Architecture, Gene Regulation, Stem Cells and Cancer Programme, Center for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID http://orcid.org/0000-0003-2117-7385
Maja Kuzman *Bioinformatics Group, Division of Molecular Biology, Department of Biology, Faculty of Science, University of Zagreb, Zagreb, Croatia.ORCID http://orcid.org/0000-0002-7490-450X
Eduard Zorita *Genome Architecture, Gene Regulation, Stem Cells and Cancer Programme, Center for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID http://orcid.org/0000-0002-0129-0885
Julia WegnerDepartment of Infectious Diseases, Integrative Virology, Heidelberg University Hospital and German Center for Infection Research, Heidelberg, Germany.
Vera MinnekerInstitute of Molecular Biology (IMB), Mainz, Germany.
Wei WangGerman Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
Raffaele FronzaGerman Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
Stefanie LaufsGerman Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
Manfred SchmidtGerman Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
Ralph StadhoudersDepartment of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands.
Vassilis RoukosInstitute of Molecular Biology (IMB), Mainz, Germany.ORCID http://orcid.org/0000-0002-5065-3937
Kristian Vlahovicek *Bioinformatics Group, Division of Molecular Biology, Department of Biology, Faculty of Science, University of Zagreb, Zagreb, Croatia. kristian@bioinfo.hr.ORCID http://orcid.org/0000-0002-5705-2464
Guillaume J Filion *Genome Architecture, Gene Regulation, Stem Cells and Cancer Programme, Center for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Barcelona, Spain. guillaume.filion@gmail.com.ORCID http://orcid.org/0000-0002-3473-1632
Marina Lusic *Department of Infectious Diseases, Integrative Virology, Heidelberg University Hospital and German Center for Infection Research, Heidelberg, Germany. Marina.lusic@med.uni-heidelberg.de.ORCID http://orcid.org/0000-0002-0120-3569
German Cancer Research Center · DEHeidelberg University · DEUniversitat Pompeu Fabra · ESInstitute of Molecular Biology · DEUniversity of Zagreb · HRErasmus MC · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HIV-1 recurrently targets active genes and integrates in the proximity of the nuclear pore compartment in CD4

Indexed as

Enhancer Elements, GeneticBase SequenceCD4-Positive T-LymphocytesCell NucleusChromatinHIV-1HIV InfectionsHumansNuclear PorePromoter Regions, GeneticTranscription, GeneticVirus IntegrationChromatin

Identifiers

PMID31492853
PMCPMC6731298
OpenAlexW2972200133

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.