Evidence map›Paper›PMID 31492841›Full record

ArticleNature communications2019

Similarities and differences in patterns of germline mutation between mice and humans.

Sarah J Lindsay, Raheleh Rahbari, Joanna Kaplanis, Thomas Keane, Matthew E Hurles

Abstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  15. Increased rate ofbioRxiv : the preprint server for biology · 2025
    Article
  16. Article
  17. Population size interacts with reproductive longevity to shape the germline mutation rate.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  18. Article
  19. Article
  20. Review

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sarah J LindsayWellcome Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.ORCID http://orcid.org/0000-0002-0965-3070
Raheleh RahbariWellcome Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.ORCID http://orcid.org/0000-0002-1839-7785
Joanna KaplanisWellcome Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
Thomas KeaneWellcome Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.ORCID http://orcid.org/0000-0001-7532-6898
Matthew E HurlesWellcome Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK. meh@sanger.ac.uk.

Funding

Medical Research Council MR/R017565/1Wellcome Trust
6 · The paper itself

Abstract

Whole genome sequencing (WGS) studies have estimated the human germline mutation rate per basepair per generation (~1.2 × 10

Indexed as

Germ-Line MutationMutation RateAnimalsCell DivisionEmbryonic DevelopmentFemaleGametogenesisGerm CellsHumansMaleMaternal AgeMicePaternal AgePedigreeSpecies SpecificityWhole Genome Sequencing

Identifiers

PMID31492841
PMCPMC6731245

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.