Evidence map›Paper›PMID 31492772›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Degeneration of Injured Axons and Dendrites Requires Restraint of a Protective JNK Signaling Pathway by the Transmembrane Protein Raw.

Yan Hao, Thomas J Waller, Derek M Nye, Jiaxing Li, Yanxiao Zhang, Richard I Hume, Melissa M Rolls, Catherine A Collins

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Peripheral Nerve Crush inCold Spring Harbor protocols · 2025
    Article
  5. Article
  6. A nerve-wracking buzz: lessons fromFrontiers in aging neuroscience · 2023
    Review
  7. Article
  8. Multifaceted roles of SARM1 in axon degeneration and signaling.Frontiers in cellular neuroscience · 2022
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yan HaoDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109-1085.ORCID 0000-0002-4468-1704
Thomas J WallerDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109-1085.ORCID 0000-0002-3098-9070
Derek M NyeHuck Institutes of the Life Sciences, and Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, and.
Jiaxing LiDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109-1085.ORCID 0000-0001-5604-4916
Yanxiao ZhangDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109-2218.
Richard I HumeDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109-1085.ORCID 0000-0001-9807-112X
Melissa M RollsHuck Institutes of the Life Sciences, and Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, and.ORCID 0000-0002-5021-4360
Catherine A CollinsDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109-1085, collinca@umich.edu.ORCID 0000-0002-1608-6692
University of Michigan · USPennsylvania State University · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Drosophila Transgenic RNAi Resource ProjectR01GM084947 · NIGMS · HARVARD MEDICAL SCHOOL · PI PERRIMON, NORBERT · 2008 to 2019
$9.8M
Using Drosophila Neurons to Identify Mechanisms that Control Microtubule PolarityR01GM085115 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Melissa Rolls · 2010 to 2026
$5.1M
Regenerative and Degenerative Responses to Axonal InjuryR01NS069844 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CADIGAN, KENNETH M, COLLINS, CATHERINE A · 2010 to 2024
$5.0M
NIGMS NIH HHS R01 GM084947NIGMS NIH HHS R01 GM085115NIH HHS P40 OD018537NINDS NIH HHS R01 NS069844
6 · The paper itself

Abstract

The degeneration of injured axons involves a self-destruction pathway whose components and mechanism are not fully understood. Here, we report a new regulator of axonal resilience. The transmembrane protein Raw is cell autonomously required for the degeneration of injured axons, dendrites, and synapses in

Indexed as

AnimalsAnimals, Genetically ModifiedAxonsCytoskeletal ProteinsDendritesDrosophila melanogasterDrosophila ProteinsFemaleJNK Mitogen-Activated Protein KinasesMaleMAP Kinase Signaling SystemMotor NeuronsNerve DegenerationSynapsesCytoskeletal ProteinsDrosophila ProteinsJNK Mitogen-Activated Protein Kinasesraw protein, Drosophilaaxon degenerationaxon injuryDrosophilaMAP kinase signalingmotoneuronWallerian degeneration

Identifiers

PMID31492772
PMCPMC6807270
OpenAlexW2972277762

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.