ArticleJournal of immunology (Baltimore, Md. : 1950)2019
Inferring the "Primordial Immune Complex": Origins of MHC Class I and Antigen Receptors Revealed by Comparative Genomics.
Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 40 citations in OpenAlex.
- A comprehensive and accessible database of jawed-vertebrate ohnologs.Science advances · 2026Article
- A chromosome-level reference genome for the colonial marine hydrozoan Podocoryna americana.G3 (Bethesda, Md.) · 2026Article
- A chromosome-level genome assembly for the colonial marine hydrozoanbioRxiv : the preprint server for biology · 2026Article
- MHC in newts illuminates the evolutionary dynamics of complex regions in giant genomes.Genome research · 2026Article
- Review
- Origin of immunoglobulins and T cell receptors: A candidate gene for invasion by the RAG transposon.Science advances · 2025Article
- Understanding vertebrate immunity through comparative immunology.Nature reviews. Immunology · 2025Review
- Functional insights into immunoglobulin superfamily proteins in invertebrate neurobiology and immunity.Frontiers in immunology · 2025Review
- The Janus (dual) model of immunoglobulin isotype evolution: Conservation and plasticity are the defining paradigms.Immunological reviews · 2024Review
- An Ancestral Major Histocompatibility Complex Organization in Cartilaginous Fish: Reconstructing MHC Origin and Evolution.Molecular biology and evolution · 2023Article
- Genomic view of the origins of cell-mediated immunity.Immunogenetics · 2023Article
- An Ancient MHC-Linked Gene Encodes a Nonrearranging Shark Antibody, UrIg, Convergent with IgG.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Advances in the Xenopus immunome: Diversification, expansion, and contraction.Developmental and comparative immunology · 2023Review
- MHC architecture in amphibians - ancestral reconstruction, gene rearrangements and duplication patterns.Genome biology and evolution · 2023Article
- Extensive MHC class IIβ diversity across multiple loci in the small-spotted catshark (Scyliorhinus canicula).Scientific reports · 2023Article
- Some thoughts about what non-mammalian jawed vertebrates are telling us about antigen processing and peptide loading of MHC molecules.Current opinion in immunology · 2022Review
- The new W family reconstructs the evolution of MHC genes.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- On the relationship between extant innate immune receptors and the evolutionary origins of jawed vertebrate adaptive immunity.Immunogenetics · 2022Review
- Identification of the Fc-alpha/mu receptor in Xenopus provides insight into the emergence of the poly-Ig receptor (pIgR) and mucosal Ig transport.European journal of immunology · 2021Article
- Major histocompatibility complex genes and locus organization in the Komodo dragon (Varanus komodoensis).Immunogenetics · 2021Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Comparative analyses suggest that the MHC was derived from a prevertebrate "primordial immune complex" (PIC). PIC duplicated twice in the well-studied two rounds of genome-wide duplications (2R) early in vertebrate evolution, generating four MHC paralogous regions (predominantly on human chromosomes [chr] 1, 6, 9, 19). Examining chiefly the amphibian
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.