Evidence map›Paper›PMID 31492721›Full record

ArticleTobacco control2020

Waterpipe tobacco smoke toxicity: the impact of waterpipe size.

Cindy DeForest Hauser, Ronnae Mailig, Hannah Stadtler, Jenna Reed, Shi Chen, Emilie Uffman, Karen Bernd

Open access · bronzeAbstract readCase ReportsComparative Study
In one paragraph

Article in Tobacco control, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Waterpipe Size Matters: The Effect of Waterpipe Size on Toxicant Exposures and Subjective Experiences.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Cindy DeForest HauserDepartment of Chemistry, Davidson College, Davidson, North Carolina, USA.
Ronnae MailigDepartment of Chemistry, Davidson College, Davidson, North Carolina, USA.
Hannah StadtlerDepartment of Biology, Davidson College, Davidson, North Carolina, USA.
Jenna ReedDepartment of Biology, Davidson College, Davidson, North Carolina, USA.
Shi ChenDepartment of Biology, Davidson College, Davidson, North Carolina, USA.
Emilie UffmanDepartment of Biology, Davidson College, Davidson, North Carolina, USA.
Karen BerndDepartment of Biology, Davidson College, Davidson, North Carolina, USA kabernd@davidson.edu.ORCID 0000-0002-0743-2848
Davidson College · US

Funding

Impact of waterpipe configuration on the size distribution and number density of smoke particles and targeted chemical analysis of particle profiles that diminish alveolar cell healthR01HL134169 · NHLBI · DAVIDSON COLLEGE · PI BERND, KAREN K, HAUSER, CINDY DEFOREST · 2016 to 2018
$447k
NHLBI NIH HHS R01 HL134169
6 · The paper itself

Abstract

introductionWaterpipe tobacco smoking continues to show increasing popularity, especially among individuals between 18 and 22 years old. Waterpipe tobacco smoke (WTS) is a mixture of particulates and gases formed from the combustion of the charcoal and volatilisation and humidification of the tobacco+humectant+flavouring substrate known as shisha or mu'assel. As such, variation in the configuration of the waterpipe may affect the particles produced. Our study focuses on the effects of waterpipe size on the physical properties and cytotoxicity of the smoke produced.

methodsShisha type and headspace volume were held constant and a modified Beirut puff protocol was followed while the size of the waterpipe was varied. Particle concentrations and size distributions were measured using a TSI Engine Exhaust Particle Sizer. Type II alveolar cells were exposed to smoke at the air-liquid interface and two metrics of cell health analysed.

resultsIn a 30 min session, we observed a decrease in total particle concentration (10

conclusionSmoke from waterpipes of all sizes causes significant alveolar cellular harm, indicating that this device needs regulation as a hazard to human health.

Indexed as

Smoking Water PipesAlveolar Epithelial CellsAnimalsCells, CulturedCell SurvivalHumansParticle SizeRatsSmokeTobacco, WaterpipeWater Pipe SmokingSmokeair-liquid interfaceparticulate mattershishatoxicitywaterpipewaterpipe tobacco smoke

Identifiers

PMID31492721
PMCPMC7839942
OpenAlexW2971849374

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.