Evidence map›Paper›PMID 31492649›Full record

ArticleImmunity2019

A Molecular Signature in Blood Reveals a Role for p53 in Regulating Malaria-Induced Inflammation.

Tuan M Tran, Rajan Guha, Silvia Portugal, Jeff Skinner, Aissata Ongoiba, Jyoti Bhardwaj, Marcus Jones, Jacqueline Moebius, Pratap Venepally, Safiatou Doumbo and 15 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.

  1. Pooled it
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  4. bioRxiv : the preprint server for biology · 2026
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  5. CumulativeFrontiers in cellular and infection microbiology · 2026
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors at 8 institutions in 3 countries.

Tuan M TranMalaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852, USA; Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Ryan White Center for Pediatric Infectious Disease and Global Health, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Electronic address: tuantran@iu.edu.
Rajan GuhaMalaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852, USA.
Silvia PortugalMalaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852, USA; Center for Infectious Diseases-Parasitology, Heidelberg University Hospital, Heidelberg 69120, Germany.
Jeff SkinnerMalaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852, USA.
Aissata OngoibaMali International Center of Excellence in Research, University of Sciences, Technique and Technology of Bamako, BP 1805, Point G, Bamako, Mali.
Jyoti BhardwajDivision of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Ryan White Center for Pediatric Infectious Disease and Global Health, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Marcus JonesGenomic Medicine Group, J. Craig Venter Institute, Rockville, MD 20850, USA.
Jacqueline MoebiusMalaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852, USA.
Pratap VenepallyGenomic Medicine Group, J. Craig Venter Institute, Rockville, MD 20850, USA.
Safiatou DoumboMali International Center of Excellence in Research, University of Sciences, Technique and Technology of Bamako, BP 1805, Point G, Bamako, Mali.
Elizabeth A DeRisoRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.
Shanping LiMalaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852, USA.
Kamalakannan VijayanCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA.
Sarah L AnzickRocky Mountain Laboratories, Genomics Unit, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840, USA.
Geoffrey T HartMalaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852, USA; Division of Infectious Disease and International Medicine, Department of Medicine, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
Elise M O'ConnellLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
Ogobara K DoumboMali International Center of Excellence in Research, University of Sciences, Technique and Technology of Bamako, BP 1805, Point G, Bamako, Mali.
Alexis KaushanskyCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA.
Galit AlterRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.
Phillip L FelgnerDivision of Infectious Diseases, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA.
Hernan LorenziDepartment of Infectious Diseases, J. Craig Venter Institute, Rockville, MD 20850, USA.
Kassoum KayentaoMali International Center of Excellence in Research, University of Sciences, Technique and Technology of Bamako, BP 1805, Point G, Bamako, Mali.
Boubacar TraoreMali International Center of Excellence in Research, University of Sciences, Technique and Technology of Bamako, BP 1805, Point G, Bamako, Mali.
Ewen F KirknessGenomic Medicine Group, J. Craig Venter Institute, Rockville, MD 20850, USA.
Peter D CromptonMalaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852, USA. Electronic address: pcrompton@niaid.nih.gov.
National Institute of Allergy and Infectious Diseases · USUniversité des Sciences, des Techniques et des Technologies de Bamako · MLJ. Craig Venter Institute · USInfectious Disease Research Institute · USRagon Institute of MGH, MIT and Harvard · USHeidelberg University · DEIndiana University Health · USUniversity of California, Irvine · US

Funding

Mechanisms of naturally-acquired immunity to malaria and clinical trials of anti-malaria monoclonal antibodiesZIAAI001155 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CROMPTON, PETER · 2011 to 2025
$30.9M
The J. Craig Venter Institute Genome Center for Infectious DiseasesU19AI110819 · NIAID · J. CRAIG VENTER INSTITUTE, INC. · PI TAN, GENE · 2014 to 2018
$29.7M
TransmissionU19AI089686 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI KAZURA, JAMES WALTER · 2010 to 2016
$9.9M
Perturbations of host cell signaling by a complex hepatotropic pathogenR01GM101183 · NIGMS · SEATTLE CHILDREN'S HOSPITAL · PI KAUSHANSKY, ALEXIS · 2013 to 2021
$3.6M
Predicting naturally acquired humoral immunity against malariaR01AI095916 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI FELGNER, PHILIP LOUIS · 2012 to 2016
$2.1M
Defining clinical and sterile immunity to Plasmodium falciparum infection using systems biology approachesK08AI125682 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI TRAN, TUAN MANH · 2017 to 2021
$926k
Intramural NIH HHS ZIA AI001155NIAID NIH HHS HHSN272200900007CNIAID NIH HHS K08 AI125682NIAID NIH HHS R01 AI095916NIAID NIH HHS U19 AI089686NIAID NIH HHS U19 AI110819NIGMS NIH HHS R01 GM101183Wellcome Trust
6 · The paper itself

Abstract

Immunity that controls parasitemia and inflammation during Plasmodium falciparum (Pf) malaria can be acquired with repeated infections. A limited understanding of this complex immune response impedes the development of vaccines and adjunctive therapies. We conducted a prospective systems biology study of children who differed in their ability to control parasitemia and fever following Pf infection. By integrating whole-blood transcriptomics, flow-cytometric analysis, and plasma cytokine and antibody profiles, we demonstrate that a pre-infection signature of B cell enrichment, upregulation of T helper type 1 (Th1) and Th2 cell-associated pathways, including interferon responses, and p53 activation associated with control of malarial fever and coordinated with Pf-specific immunoglobulin G (IgG) and Fc receptor activation to control parasitemia. Our hypothesis-generating approach identified host molecules that may contribute to differential clinical outcomes during Pf infection. As a proof of concept, we have shown that enhanced p53 expression in monocytes attenuated Plasmodium-induced inflammation and predicted protection from fever.

Indexed as

AdolescentAdultAnimalsAntibodies, ProtozoanBlood ProteinsB-LymphocytesChildChild, PreschoolDisease ResistanceFemaleGene Expression ProfilingHumansInfantInflammationInterferonsMalaria, FalciparumAntibodies, ProtozoanBlood ProteinsInterferonsReceptors, FcTumor Suppressor Protein p53antibody profilingflow cytometrymalariamalaria immunityPlasmodium falciparumprospective cohort studyRNA-seqRNA sequencingsystems biologysystems immunologytranscriptomics

Identifiers

PMID31492649
PMCPMC7163400
OpenAlexW2971926893

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.