ArticleEarly human development2020
The significance of the low sex ratios of offspring and of sibs of probands with systemic lupus erythematosus or rheumatoid arthritis.
Article in Early human development, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
There is good evidence that there are significantly low sex ratios (proportions male) in the offspring of patients with some immune diseases e.g. systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). There is also strong evidence that there are significantly low sex ratios in the sibs of patients with SLE and RA and it has been suggested that the low SLE sib sex ratio may be explained by male fetal loss. However, no explanations for these low sex ratios has been established. Bearing in mind the posited hormonal involvement in immune processes, this paper suggesst an additional potential solution. It is that both the pathology and the sex ratio share a hormonal cause - testosterone. The argument depends on the hormonal hypothesis of sex ratio. This paper will describe the hypothesis and describe its relevance to SLE and RA.
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