ArticleBritish journal of anaesthesia2019
Electroencephalographic slow wave dynamics and loss of behavioural responsiveness induced by ketamine in human volunteers.
Article in British journal of anaesthesia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 27 citations in OpenAlex.
- Ketamine in super-refractory status epilepticus: Combined value of inflammatory biomarkers and EEG features.Epilepsia · 2026Observational
- Signal, Not Noise: Aperiodic Dynamics in the Electroencephalogram Under Anesthesia.Anesthesia and analgesia · 2026Article
- Ketamine in clinical practice: transitioning from anesthetic agent to psychiatric therapeutic.CNS spectrums · 2025Review
- The collective lie in ketamine therapy: a call to realign clinical practice with neurobiology.Frontiers in psychiatry · 2025Article
- FluoAnalysis: An Open-Source MATLAB Toolbox for Analysis of Calcium Imaging Measurements of Oscillatory Astrocytic and Neuronal Networks.Brain sciences · 2024Article
- High-Frequency Imaging Reveals Synchronised Delta- and Theta-Band CaInternational journal of molecular sciences · 2024Article
- Neurological sedative indicators during general anesthesia with remimazolam.Journal of anesthesia · 2022Article
- Targeting Affective Mood Disorders With Ketamine to Prevent Chronic Postsurgical Pain.Frontiers in pain research (Lausanne, Switzerland) · 2022Review
- Ketamine-50 years in use: from anesthesia to rapid antidepressant effects and neurobiological mechanisms.Pharmacological reports : PR · 2021Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundPrevious work on the electroencephalographic (EEG) effects of anaesthetic doses of ketamine has identified a characteristic signature of increased high frequency (beta-gamma) and theta waves alternating with episodic slow waves. It is unclear which EEG parameter is optimal for pharmacokinetic-pharmacodynamic modelling of the hypnotic actions of ketamine, or which EEG parameter is most closely linked to loss of behavioural responsiveness.
methodsWe re-analysed previously published 128-channel scalp EEG data from 15 subjects who had received a 1.5 mg kg
resultsHypnotic doses of ketamine i.v. induced medio-frontal EEG slow waves, and loss of behavioural response when the estimated brain concentration was 1.64 (0.17) μg ml
conclusionsChanges in EEG slow wave activity after a hypnotic dose of ketamine could be fitted by a standard sigmoid dose-response model. Their onset, but not their offset, was consistently associated with loss of behavioural response in our small study group.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.