Evidence map›Paper›PMID 31492170›Full record

ArticleBMC research notes2019

Safety and tolerance of lymph node biopsies from chronic HIV-1 volunteers in rural Tanzania.

Catherine Gerald Mkindi, Elias Antony Marandu, Ngisi Masawa, Farida Bani, Amina Nyuri, Theonestina Byakuzana, Thomas Klimkait, Song Ding, Giuseppe Pantaleo, Manuel Battegay and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Catherine Gerald MkindiDepartment of Medical Parasitology and Infection Biology, Clinical Immunology, Swiss Tropical and Public Health Institute, Socinstr. 57, 4002, Basel, Switzerland.
Elias Antony MaranduSt Francis Referral Hospital, Ifakara, Tanzania.
Ngisi MasawaIfakara Health Institute, Bagamoyo, Tanzania.
Farida BaniIfakara Health Institute, Bagamoyo, Tanzania.
Amina NyuriIfakara Health Institute, Bagamoyo, Tanzania.
Theonestina ByakuzanaIfakara Health Institute, Bagamoyo, Tanzania.
Thomas KlimkaitUniversity of Basel, Basel, Switzerland.
Song DingEuroVacc Foundation, Amsterdam, The Netherlands.
Giuseppe PantaleoService of Immunology and Allergy, Lausanne University Hospital, Lausanne, Switzerland.
Manuel BattegayDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland.
Nina Orlova-FinkDepartment of Medical Parasitology and Infection Biology, Clinical Immunology, Swiss Tropical and Public Health Institute, Socinstr. 57, 4002, Basel, Switzerland.
Maja Weisser-RohacekDepartment of Medical Parasitology and Infection Biology, Clinical Immunology, Swiss Tropical and Public Health Institute, Socinstr. 57, 4002, Basel, Switzerland.
Claudia DaubenbergerDepartment of Medical Parasitology and Infection Biology, Clinical Immunology, Swiss Tropical and Public Health Institute, Socinstr. 57, 4002, Basel, Switzerland. claudia.daubenberger@swisstph.ch.ORCID http://orcid.org/0000-0001-7136-0642
Ifakara Health Institute · TZSt. Francis Referral Hospital · TZSwiss Vaccine Research Institute · CHUniversity Hospital of Basel · CHUniversity of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveHIV-1 rapidly establishes a persistent infection that can be contained under life-long antiretroviral therapy (ART) but not cured. One major viral reservoir is the peripheral lymph node (LN) follicles. Studying the impact of novel HIV-1 treatment and vaccination approaches on cells residing in germinal centers is essential for rapid progress towards HIV-1 prevention and cure.

resultsWe enrolled 9 asymptomatic adult volunteers with a newly diagnosed HIV-1 infection and CD4 T cell counts ≥ 350/ml. The patients underwent venous blood collection and inguinal lymph node excision surgery in parallel. Mononuclear cells were extracted from blood and tissues simultaneously. Participants were followed up regularly for 2 weeks until complete healing of the surgical wounds. All participants completed the lymph node excision surgery without clinical complications. Among the 9 volunteers, one elite controller was identified. The number of mononuclear cells recovered from lymph nodes ranged from 68 to 206 million and correlated positively with lymph node size. This is the first study to show that lymph node biopsy is a safe procedure and can be undertaken with local experts in rural settings. It provides a foundation for detailed immune response investigations during future clinical trials.

Indexed as

CD4 Lymphocyte CountAdultAnti-Retroviral AgentsChronic DiseaseFemaleHIV-1HIV InfectionsHumansLymph Node ExcisionLymph NodesMaleMiddle AgedReproducibility of ResultsRural PopulationTanzaniaVolunteersAnti-Retroviral AgentsChronicElite controllerHIV-1KIULARCO cohortLymph node biopsyTanzania

Identifiers

PMID31492170
PMCPMC6729032
OpenAlexW2971681462

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.