Evidence map›Paper›PMID 31492161›Full record

ReviewAIDS research and therapy2019

Leveraging early HIV diagnosis and treatment in Thailand to conduct HIV cure research.

Camilla Muccini, Trevor A Crowell, Eugène Kroon, Carlo Sacdalan, Reshmie Ramautarsing, Pich Seekaew, Praphan Phanuphak, Jintanat Ananworanich, Donn J Colby, Nittaya Phanuphak

Abstract readReview
In one paragraph

Review in AIDS research and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Camilla MucciniVita-Salute San Raffaele University, via Stamira D'Ancona 20, 20127, Milan, Italy. muccini.camilla@hsr.it.
Trevor A CrowellU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, USA.
Eugène KroonSEARCH, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Carlo SacdalanSEARCH, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Reshmie RamautarsingPREVENTION, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Pich SeekaewPREVENTION, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Praphan PhanuphakSEARCH, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Jintanat AnanworanichU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, USA.
Donn J ColbySEARCH, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Nittaya PhanuphakSEARCH, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.

Funding

Henry M. Jackson Foundation W81XWH-18-2-0040U.S. Department of Defense W81XWH-18-2-0040
6 · The paper itself

Abstract

Thailand has the highest prevalence of HIV among countries in Asia but has also been a pioneer in HIV prevention and treatment efforts in the region, reducing the incidence of new infections significantly over the last two decades. Building upon this remarkable history, Thailand has set an ambitious goal to stop the AIDS epidemic in the country by 2030. A key component of the strategy to achieve this goal includes scale-up of HIV screening programs to facilitate early HIV diagnosis and investment in mechanisms to support immediate initiation of antiretroviral therapy (ART). Initiation of ART during early or acute HIV infection not only reduces viremia, thereby halting onward transmission of HIV, but also may facilitate HIV remission by reducing the size of the latent HIV reservoir and preserving immune function. In Thailand, many efforts have been made to reduce the time from HIV infection to diagnosis and from diagnosis to treatment, especially among men who have sex with men and transgender women. Successfully identifying and initiating ART in individuals with acute HIV infection has been leveraged to conduct groundbreaking studies of novel strategies to achieve HIV remission, including studies of broadly-neutralizing HIV-specific monoclonal antibodies and candidate therapeutic vaccines. These efforts have mostly been deployed in Bangkok and future efforts should include other urban and more rural areas. Continued progress in HIV prevention, screening, and treatment will position Thailand to substantially limit new infections and may pave the way for an HIV cure.

Indexed as

ResearchAcquired Immunodeficiency SyndromeAnti-HIV AgentsClinical Trials as TopicEarly DiagnosisHIV-1HIV InfectionsHomosexuality, MaleHumansMalePrevalenceRisk FactorsSexual BehaviorThailandAnti-HIV AgentsAcquired immunodeficiency syndromeAIDS serodiagnosisAIDS vaccinesAnti-retroviral agentsDisease reservoirsHighly active antiretroviral therapyHIV antibodiesHIV seropositivity

Identifiers

PMID31492161
PMCPMC6729012

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.