Evidence map›Paper›PMID 31492135›Full record

ArticleMalaria journal2019

Exploration of genetic diversity of Plasmodium vivax circumsporozoite protein (Pvcsp) and Plasmodium vivax sexual stage antigen (Pvs25) among North Indian isolates.

Hargobinder Kaur, Rakesh Sehgal, Archit Kumar, Alka Sehgal, Praveen K Bharti, Devendra Bansal, Pradyumna K Mohapatra, Jagadish Mahanta, Ali A Sultan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Malaria journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 21 citations in OpenAlex.

  1. Population Dynamics ofMicroorganisms · 2025
    Article
  2. Article
  3. Article
  4. Genetic Diversity ofTropical medicine and infectious disease · 2023
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Hargobinder KaurDepartment of Medical Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Rakesh SehgalDepartment of Medical Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India. sehgalpgi@gmail.com.
Archit KumarDepartment of Virology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Alka SehgalDepartment of Obstt. & Gynae, Government Medical College and Hospital, Chandigarh, India.
Praveen K BhartiNational Institute for Research in Tribal Health, Indian Council of Medical Research, Nagpur Road, Garha, Jabalpur, Madhya Pradesh, India.
Devendra BansalDepartment of Microbiology and Immunology, Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation-Education City, Doha, Qatar.
Pradyumna K MohapatraRegional Medical Research Centre, NE, Indian Council of Medical Research, Post Box no.105, Dibrugarh, Assam, India.
Jagadish MahantaRegional Medical Research Centre, NE, Indian Council of Medical Research, Post Box no.105, Dibrugarh, Assam, India.
Ali A SultanDepartment of Microbiology and Immunology, Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation-Education City, Doha, Qatar.
Post Graduate Institute of Medical Education and Research · INIndian Council of Medical Research · INWeill Cornell Medical College in Qatar · QAGovernment Medical College and Hospital · INRegional Medical Research Centre · IN

Funding

Qatar National Research Fund NPRP 5- 098-3-021
6 · The paper itself

Abstract

backgroundMalaria is one of the important vector-borne diseases with high fatality rates in tropical countries. The pattern of emergence and spread of novel antigenic variants, leading to escape of vaccine-induced immunity might be factors responsible for severe malaria. A high level of polymorphism has been reported among malarial antigens which are under selection pressure imposed by host immunity. There are limited reports available on comparative stage-specific genetic diversity among Plasmodium vivax candidate genes in complicated vivax malaria. The present study was planned to study genetic diversity (Pvcsp and Pvs25) among complicated and uncomplicated P. vivax isolates.

methodsPvcsp and Pvs2-specific PCRs and DNA sequencing were performed on P. vivax PCR positive samples. Genetic diversity was analysed using appropriate software.

resultsThe present study was carried out on 143 P. vivax clinical isolates, collected from Postgraduate Institute of Medical Education and Research, Chandigarh. Among the classic and variant types of Pvcsp, the VK210 (99%; 115/116) was found to be predominant in both complicated and uncomplicated group isolates. Out of the various peptide repeat motifs (PRMs) observed, GDRADGQPA (PRM1) and GDRAAGQPA (PRM2) was the most widely distributed among the P. vivax isolates. Whereas among the Pvs25 isolates, 100% of double mutants (E97Q/I130T) in both the complicated (45/45) as well as in the uncomplicated (81/81) group was observed.

conclusionAn analysis of genetic variability enables an understanding of the role of genetic variants in severe vivax malaria.

Indexed as

Genetic VariationAdolescentAdultAntigens, ProtozoanAntigens, SurfaceChildFemaleHumansIndiaMalaria VaccinesMalePlasmodium vivaxProtozoan ProteinsYoung AdultAntigens, ProtozoanAntigens, Surfacecircumsporozoite protein, ProtozoanMalaria VaccinesProtozoan ProteinsPvs25 protein, P vivaxGenetic diversityPlasmodium vivaxPvcspPvs25

Identifiers

PMID31492135
PMCPMC6731556
OpenAlexW2971768810

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.