ReviewThe journal of headache and pain2019
Differences in treatment response between migraine with aura and migraine without aura: lessons from clinical practice and RCTs.
Review in The journal of headache and pain, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Approach to headache disorders and the management of migraine: consensus guidelines from the Headache Society of Singapore, first edition (2023).Singapore medical journal · 2026Guideline
- The impact of caffeine consumption on migraine: a systematic review.BMC neurology · 2026Pooled it
- Which is the best transcranial direct current stimulation protocol for migraine prevention? A systematic review and critical appraisal of randomized controlled trials.The journal of headache and pain · 2021Pooled it
- Migraine phases and treatment response: a post hoc analysis of participants with migraine with aura from the TEAM study.BMC neurology · 2026Trial
- Effect and Safety of Phytosomal Curcumin Supplementation on Migraine Patients: A Randomized, Double-Blind and Placebo-Controlled Trial.Chinese journal of integrative medicine · 2025Trial
- Does high aura frequency in migrainous healthcare workers point out underestimated migraine aura in the general population?Acta neurologica Belgica · 2026Article
- Observational
- How We Can Optimize Dysmenorrhea Treatment: Real-World Results from a Cross-Sectional, Multi-Center Study.Geburtshilfe und Frauenheilkunde · 2026Article
- Unveiling migraine subtype heterogeneity and risk loci: integrated genome-wide association study and single-cell transcriptomics discovery.The journal of headache and pain · 2025Article
- Diffusion tensor image analysis along the perivascular space index and visual analogue scales in female patients with patent foramen ovale and migraine perform better after percutaneous closure.Quantitative imaging in medicine and surgery · 2025Article
- Association of migraine treatments with reduced ischemic stroke risk: Evidence from two large-scale real-world data analyses.Headache · 2025Article
- Migraine with and without aura-two distinct entities? A narrative review.The journal of headache and pain · 2025Review
- Impaired glymphatic system in patent foramen ovale based on diffusion tensor imaging analysis along the perivascular space.Quantitative imaging in medicine and surgery · 2025Article
- Dissecting the Circle of Willis-Migraine connection: A review.AIMS neuroscience · 2025Review
- The Potential Role of Glutamate Receptors and their Antagonists or Modulators in Migraine Therapy.Current neuropharmacology · 2025Review
- Causal relationships between cortical brain structural alterations and migraine subtypes: a bidirectional Mendelian randomization study of 2,347 neuroimaging phenotypes.The journal of headache and pain · 2024Article
- Resolution of Migraine with Aura Post-PFO Closure in a Young Female: A Case Report.The American journal of case reports · 2024Article
- Stroke Risk Reduction in Migraine Patients Using Propranolol: Evidence from Two Large-Scale Real-World Data Analyses.medRxiv : the preprint server for health sciences · 2024Article
- Migraine headache (MH) classification using machine learning methods with data augmentation.Scientific reports · 2024Article
- Real-world observations and impacts of Chinese herbal medicine for migraine: results of a registry-based cohort study.Frontiers in pharmacology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Migraine is a major public health problem afflicting approximately 10% of the general population and is a leading cause of disability worldwide, yet our understanding of the basis mechanisms of migraine remains incomplete. About a third of migraine patients have attacks with aura, consisting of transient neurological symptoms that precede or accompany headache, or occur without headache. For patients, aura symptoms are alarming and may be transiently disabling. For clinicians and scientists, aura represents an intriguing neurophysiological event that may provide important insight into basic mechanisms of migraine. Several observations point toward important differences between migraine with and without aura. Compared with migraine without aura, migraine with aura has different heritability, greater association with different conditions including stroke, different alterations of brain structure and function as revealed by imaging studies. A number of studies also indicate that migraine with aura may respond differently to acute and preventive therapies as compared to migraine without aura. The purpose of this review is to provide an overview of these differences in treatment responses, and to discuss the possibility of different therapeutic strategies for migraine with vs. without aura.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.