ArticleMolecules (Basel, Switzerland)2019
A Three-Step, Gram-Scale Synthesis of Hydroxytyrosol, Hydroxytyrosol Acetate, and 3,4-Dihydroxyphenylglycol.
Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Novel hydroxytyrosol esters as potential anti-amyloid and neuroprotective agents for Alzheimer's disease.RSC medicinal chemistry · 2026Article
- Adjuvant potential ofPharmaceutical biology · 2025Article
- Geographical Origin Authentication of Leaves and Drupes fromMolecules (Basel, Switzerland) · 2025Article
- Synthesis of hydroxytyrosol analogs with enhanced antioxidant and cytostatic properties against MG-63 human osteoblast-like cells and their potential implications for bone health.Archiv der Pharmazie · 2025Article
- Foliar Nutrition Strategies for Enhancing Phenolic and Amino Acid Content in Olive Leaves.Plants (Basel, Switzerland) · 2024Article
- Mitochondria-Targeted Triphenylphosphonium-Hydroxytyrosol Prevents Lipotoxicity-Induced Endothelial Injury by Enhancing Mitochondrial Function and Redox Balance via Promoting FoxO1 and Nrf2 Nuclear Translocation and Suppressing Inflammation via Inhibiting p38/NF-кB Pathway.Antioxidants (Basel, Switzerland) · 2023Article
- Effects of Oleuropein and Hydroxytyrosol on Inflammatory Mediators: Consequences on Inflammaging.International journal of molecular sciences · 2022Review
- Efficient 2-Step Enzymatic Cascade for the Bioconversion of Oleuropein into Hydroxytyrosol.Antioxidants (Basel, Switzerland) · 2022Article
- Synthesis of Tyrosol and Hydroxytyrosol Glycofuranosides and Their Biochemical and Biological Activities in Cell-Free and Cellular Assays.Molecules (Basel, Switzerland) · 2021Article
- Thiols Act as Methyl Traps in the Biocatalytic Demethylation of Guaiacol Derivatives.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2021Article
- Thiols Act as Methyl Traps in the Biocatalytic Demethylation of Guaiacol Derivatives.Angewandte Chemie (International ed. in English) · 2021Article
- Biocatalyzed Flow Oxidation of Tyrosol to Hydroxytyrosol and Efficient Production of Their Acetate Esters.Antioxidants (Basel, Switzerland) · 2021Article
- Structure-Biological Activity Relationships of Extra-Virgin Olive Oil Phenolic Compounds: Health Properties and Bioavailability.Antioxidants (Basel, Switzerland) · 2020Review
- NMR-Based Metabolic Profiling of Edible Olives-Determination of Quality Parameters.Molecules (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydroxytyrosol and two other polyphenols of olive tree, hydroxytyrosol acetate and 3,4-dihydroxyphenylglycol, are known for a wide range of beneficial activities in human health and prevention from diseases. The inability to isolate high, pure amounts of these natural compounds and the difficult and laborious procedures for the synthesis of them led us to describe herein an efficient, easy, cheap, and scaling up synthetic procedure, from catechol, via microwave irradiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.