Evidence map›Paper›PMID 31491978›Full record

ArticleMolecules (Basel, Switzerland)2019

Synthesis and Biological Evaluation of Disubstituted Pyrimidines as Selective 5-HT

Juhyeon Kim, Yoon Jung Kim, Ashwini M Londhe, Ae Nim Pae, Hyunah Choo, Hak Joong Kim, Sun-Joon Min

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Diazepine Agonists of the 5-HTJournal of medicinal chemistry · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Juhyeon KimCenter for Neuro-Medicine, Korea Institute of Science and Technology (KIST), Seoul 02792, Korea.ORCID 0000-0002-3113-5827
Yoon Jung KimDepartment of Applied Chemistry, Hanyang University, Ansan, Gyeonggi-do 15588, Korea.
Ashwini M LondheDivision of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Korea.
Ae Nim PaeDivision of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Korea.
Hyunah ChooCenter for Neuro-Medicine, Korea Institute of Science and Technology (KIST), Seoul 02792, Korea.
Hak Joong KimDepartment of Chemistry, Korea University, Seoul 02841, Korea.
Sun-Joon MinDepartment of Applied Chemistry, Hanyang University, Ansan, Gyeonggi-do 15588, Korea. sjmin@hanyang.ac.kr.ORCID 0000-0003-0867-4416
Convergence Research Center for Diagnosis Treatment and Care System of Dementia · KRHanyang University · KRKorea University · KRBio-Medical Science (South Korea) · KR

Funding

Korea Health Industry Development Institute HI16C1677, HI17C1037National Research Foundation of Korea NRF-2019R1A2C1008186
6 · The paper itself

Abstract

Here, we describe the synthesis of disubstituted pyrimidine derivatives and their biological evaluation as selective 5-HT

Indexed as

Chemistry Techniques, SyntheticDose-Response Relationship, DrugDrug StabilityMolecular Docking SimulationMolecular Dynamics SimulationMolecular StructureProtein BindingPyrimidinesReceptor, Serotonin, 5-HT2CSerotonin 5-HT2 Receptor AgonistsStructure-Activity RelationshipPyrimidinesReceptor, Serotonin, 5-HT2CSerotonin 5-HT2 Receptor Agonists5-HT2C receptorbinding affinitycell-based assaydisubstituted pyrimidineselectivity

Identifiers

PMID31491978
PMCPMC6767204
OpenAlexW2971888807

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.