Evidence map›Paper›PMID 31491870›Full record

ArticlePharmaceutics2019

Size Distribution of Colistin Delivery by Different Type Nebulizers and Concentrations During Mechanical Ventilation.

Ching-Yi Liu, Hsin-Kuo Ko, James B Fink, Gwo-Hwa Wan, Chung-Chi Huang, Yu-Chun Chen, Hui-Ling Lin

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Future Trends in Nebulized Therapies for Pulmonary Disease.Journal of personalized medicine · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ching-Yi LiuDepartment of Respiratory Therapy, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan. jingyi1105@gmail.com.
Hsin-Kuo KoDivision of Respiratory therapy, Department of Chest Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan. kuohsink@ms67.hinet.net.
James B FinkAerogen Pharma Corp., San Mateo 94402 CA, USA. fink.jim@gmail.com.
Gwo-Hwa WanDepartment of Respiratory Therapy, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan. ghwan@cgu.edu.tw.
Chung-Chi HuangDepartment of Respiratory Therapy, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan. cch4848@adm.cgmh.org.tw.
Yu-Chun ChenDivision of Respiratory therapy, Department of Chest Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan. ycchen30@vghtpe.gov.tw.
Hui-Ling LinDepartment of Respiratory Therapy, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan. huiling@mail.cgu.edu.tw.ORCID 0000-0002-8268-8907
Chang Gung University · TWNational Yang Ming Chiao Tung University · TWChang Gung University of Science and Technology · TW

Funding

Aerogen Ltd N/AMinistry of Science and Technology, Taiwan 104-2314-B-182 -025
6 · The paper itself

Abstract

Although aerosol delivery through mechanical ventilators has been used to administer various medications, little is known of administration with colistin. This in vitro evaluation aimed to evaluate size distribution of colistin delivery by different types of nebulizers and concentrations during mechanical ventilation. Colistin methanesulfonate (colistin) for injection was dissolved in 6 mL of distilled water to produce a low concentration (L; 156 mg) and a high concentration (H; 312 mg). A dose volume of 6 mL was placed in a vibrating mesh nebulizer (VMN) and a jet nebulizer (JN). The inhaled mass (mean ± SD) of the VMN-L (53.80 ± 14.79 mg) was greater than both the JN-L (19.82 ± 3.34 mg,

Indexed as

drug concentrationinhaled colistininhaled drug massjet nebulizermechanical ventilationparticle size distributionsvibrating mesh nebulizer

Identifiers

PMID31491870
PMCPMC6781281
OpenAlexW2971952243

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.