ArticleNeuroImage. Clinical2019
Cortical neurodevelopment in pre-manifest Huntington's disease.
Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Cortical complexity estimation using fractal dimension: A systematic review of the literature on clinical and nonclinical samples.The European journal of neuroscience · 2022Pooled it
- Brain organoid models of Huntington's disease shift the focus towards neurodevelopment.Disease models & mechanisms · 2025Article
- Boundary complexity of cortical and subcortical areas predicts deep brain stimulation outcomes in Parkinson's disease.Nature communications · 2025Article
- Evolution of aberrant brain-wide spatiotemporal dynamics of resting-state networks in a Huntington's disease mouse model.Clinical and translational medicine · 2024Article
- Fractal Dimension Studies of the Brain Shape in Aging and Neurodegenerative Diseases.Advances in neurobiology · 2024Article
- Aberrant cortical surface and cognition function in drug-naive first-episode schizophrenia.Annals of general psychiatry · 2022Article
- Cortical Features in Child and Adolescent Carriers of Mutant Huntingtin (mHTT).Journal of Huntington's disease · 2022Article
- Juvenile Huntington's Disease and Other PolyQ Diseases, Update on Neurodevelopmental Character and Comparative Bioinformatic Review of Transcriptomic and Proteomic Data.Frontiers in cell and developmental biology · 2021Review
- Gene Expression Profiling in Huntington's Disease: Does Comorbidity with Depressive Symptoms Matter?International journal of molecular sciences · 2020Article
- Surface-based morphometry study of the brain in benign childhood epilepsy with centrotemporal spikes.Annals of translational medicine · 2020Article
- The Neurodevelopmental Hypothesis of Huntington's Disease.Journal of Huntington's disease · 2020Review
- Developmental origins of cortical hyperexcitability in Huntington's disease: Review and new observations.Journal of neuroscience research · 2019Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe expression of the HTT CAG repeat expansion mutation causes neurodegeneration in Huntington's disease (HD).
objectivesIn light of the - mainly in-vitro - evidence suggesting an additional role of huntingtin in neurodevelopment we used 3T MRI to test the hypothesis that in CAG-expanded individuals without clinical signs of HD (preHD) there is evidence for neurodevelopmental abnormalities.
methodsWe specifically investigated the complexity of cortical folding, a measure of cortical neurodevelopment, employing a novel method to quantify local fractal dimension (FD) measures that uses spherical harmonic reconstructions.
resultsThe complexity of cortical folding differed at a group level between preHD (n = 57) and healthy volunteers (n = 57) in areas of the motor and visual system as well as temporal cortical areas. However, there was no association between the complexity of cortical folding and the loss in putamen volume that was clearly evident in preHD.
conclusionsOur results suggest that HTT CAG repeat length may have an influence on cortical folding without evidence that this leads to developmental pathology or was clinically meaningful. This suggests that the HTT CAG-repeat expansion mutation may influence the processes governing cortical neurodevelopment; however, that influence seems independent of the events that lead to neurodegeneration.
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