ArticleNeuroImage. Clinical2019
Resilience to adversity is associated with increased activity and connectivity in the VTA and hippocampus.
Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- How childhood adversity affects components of decision making.Neuroscience and biobehavioral reviews · 2025Pooled it
- A systematic review of the association between biological markers and environmental stress risk factors for adolescent depression.Journal of psychiatric research · 2021Pooled it
- The efficacy and cerebral mechanism of intradermal acupuncture for major depressive disorder: a multicenter randomized controlled trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Trial
- NgR-Dependent plasticity in a dCA3Molecular psychiatry · 2026Article
- A protocol for the Teen Bugs study: An integrative, multi-omics approach to understanding the role of the gut microbiome and mesocorticolimbic system in adolescent mental health following early adverse caregiving.Brain, behavior, & immunity - health · 2026Article
- Early Life Stress Affects Human Decision Making by Increasing Expectations of Volatility.Developmental science · 2026Article
- Article
- Relationship between psychological resilience and cognitive function on breast cancer chemotherapy patients: a person-centered method.Breast cancer (Tokyo, Japan) · 2025Article
- Narrative Review: A Neurobiological Perspective on Resilience in Youth.JAACAP open · 2025Review
- Annual Research Review: Exposure to environmental chemicals and psychosocial stress and the development of children's learning difficulties.Journal of child psychology and psychiatry, and allied disciplines · 2025Review
- Early life stress and altered social behaviors: A perspective across species.Neuroscience research · 2025Review
- Psychological and neuro-morphological predictors of resilience in healthy adults: the whole is more than the sum of its parts.Frontiers in neuroscience · 2025Review
- Secure attachment to caregiver prevents adult depressive symptoms in a sex-dependent manner: A translational study.iScience · 2024Article
- Associations between mesolimbic connectivity, and alcohol use from adolescence to adulthood.Developmental cognitive neuroscience · 2024Article
- Early life adversity impacts alterations in brain structure and food addiction in individuals with high BMI.Scientific reports · 2024Article
- Defining theNature. Mental health · 2024Article
- Article
- Resilience following childhood adversity: The need for a heuristic multilevel dynamic framework.Neuroscience applied · 2024Article
- Developmental Changes in Habenular and Striatal Social Reinforcement Responsivity Across Adolescence Linked With Substance Use.Biological psychiatry · 2023Article
- Functional Brain Connectivity Prior to the COVID-19 Outbreak Moderates the Effects of Coping and Perceived Stress on Mental Health Changes: A First Year of COVID-19 Pandemic Follow-up Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulating evidence suggests altered function of the mesolimbic reward system resulting from exposure to early adversity. The present study investigated the combined long-term impact of adversity until young adulthood on neuronal reward processing and its interaction with individual resilience processes. In this functional magnetic resonance imaging study, 97 healthy young adults performed a reward-based decision-making task. Adversity as well as resilience were assessed retrospectively using the validated childhood trauma questionnaire, trauma history questionnaire and a resilience scale. Subjects with high adversity load showed reduced reward-related bottom-up activation in the ventral striatum (VS), ventral tegmental area (VTA) and hippocampus (HP) as compared to the low adversity group. However, high resilience traits in individuals with high adversity load were associated with an increased activation in the VTA and HP, indicating a possible resilience-related protective mechanism. Moreover, when comparing groups with high to low adversity, psychophysiological interaction analyses highlighted an increased negative functional coupling between VS and VTA as well as between VS and anteroventral prefrontal cortex (avPFC) during reward acceptance, and an impaired top-down control of the VS by the avPFC during reward rejection. In turn, combination of high adversity and high resilience traits was associated with an improved functional coupling between VTA, VS and HP. Thereby, the present findings identify neural mechanisms mediating interacting effects of adversity and resilience, which could be targeted by early intervention and prevention.
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