Evidence map›Paper›PMID 31491815›Full record

ArticleNeuroImage. Clinical2019

Alterations in serotonin transporter and body image-related cognition in anorexia nervosa.

Masamichi Yokokura, Tatsuhiro Terada, Tomoyasu Bunai, Kyoko Nakaizumi, Yasuhiko Kato, Etsuji Yoshikawa, Masami Futatsubashi, Katsuaki Suzuki, Hidenori Yamasue, Yasuomi Ouchi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 3 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Brain serotonin, oxytocin, and their interaction: Relevance for eating disorders.Journal of psychopharmacology (Oxford, England) · 2025
    Review
  6. Anorexia Nervosa Across the Lifespan: A Review of Recent Literature.Focus (American Psychiatric Publishing) · 2024
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Masamichi YokokuraDepartment of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Tatsuhiro TeradaDepartment of Biofunctional Imaging, Preeminent Medical Photonics Education & Research Center, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Tomoyasu BunaiDepartment of Biofunctional Imaging, Preeminent Medical Photonics Education & Research Center, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Kyoko NakaizumiDepartment of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Yasuhiko KatoDepartment of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Etsuji YoshikawaCentral Research Laboratory, Hamamatsu Photonics K.K., Hamamatsu, Japan.
Masami FutatsubashiHamamatsu PET Imaging Center, Hamamatsu Medical Photonics Foundation, Hamamatsu, Japan.
Katsuaki SuzukiDepartment of Biofunctional Imaging, Preeminent Medical Photonics Education & Research Center, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Hidenori YamasueDepartment of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Yasuomi OuchiDepartment of Biofunctional Imaging, Preeminent Medical Photonics Education & Research Center, Hamamatsu University School of Medicine, Hamamatsu, Japan. Electronic address: ouchi@hama-med.ac.jp.
Hamamatsu University School of Medicine · JPHamamatsu Photonics (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The serotonin system has been implicated in the pathophysiology of anorexia nervosa (AN). A recent report proposed that body image distortion (BID), a core symptom of AN, may relate to abnormalities of the serotonin system, especially the serotonin transporter (5HTT). Positron emission tomography (PET) studies of underweight patients with active AN reported alterations in serotonin receptors, but not 5HTT. Here, we aimed to disclose the clinicopathophysiology of AN by focusing on 5HTT and cognitive functions, including BID, in groups with active AN. Twenty-two underweight female patients with AN (12 restricting-type AN (ANR); 10 binge-eating/purging-type AN (ANBP)) and 20 age-matched healthy female subjects underwent PET with a 5HTT radioligand [

Indexed as

AdolescentAdultAniline CompoundsAnorexia NervosaBody Dysmorphic DisordersCognitive DysfunctionFemaleHumansPositron-Emission TomographySerotonin Plasma Membrane Transport ProteinsSulfidesYoung Adult3-amino-4-(2-dimethylaminomethylphenylsulfanyl)benzonitrileAniline CompoundsSerotonin Plasma Membrane Transport ProteinsSulfidesAnorexia nervosaBody image distortionPositron emission tomographySerotonin transporter

Identifiers

PMID31491815
PMCPMC6627582
OpenAlexW2955937170

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.