Evidence map›Paper›PMID 31491811›Full record

ArticleEnvironment international2019

The cross-sectional and longitudinal association between air pollution and salivary cortisol: Evidence from the Multi-Ethnic Study of Atherosclerosis.

Anjum Hajat, Marnie F Hazlehurst, Sherita Hill Golden, Sharon Stein Merkin, Teresa Seeman, Adam A Szpiro, Joel D Kaufman, Ana Diez Roux

Abstract read
In one paragraph

Article in Environment international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Review
  5. Association between prenatal and childhood PMEnvironmental epidemiology (Philadelphia, Pa.) · 2024
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Environmental Toxins and Brain: Life on Earth is in Danger.Annals of Indian Academy of Neurology · 2022
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Ambient PMInhalation toxicology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anjum HajatUniversity of Washington, Department of Epidemiology, Box 357236, Seattle, WA 98195, USA. Electronic address: anjumh@uw.edu.
Marnie F HazlehurstUniversity of Washington, Department of Epidemiology, Box 357236, Seattle, WA 98195, USA. Electronic address: marnieh@uw.edu.
Sherita Hill GoldenJohns Hopkins University, Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, 1830 E. Monument Street, Room 9052, Baltimore, MD 21287, USA. Electronic address: sahill@jhmi.edu.
Sharon Stein MerkinUniversity of California Los Angeles, Geffen School of Medicine, Division of Geriatrics, 10945 Le Conte Avenue, Suite 2339, Los Angeles, CA 90095, USA. Electronic address: SMerkin@mednet.ucla.edu.
Teresa SeemanUniversity of California Los Angeles, Geffen School of Medicine, Division of Geriatrics, 10945 Le Conte Avenue, Suite 2339, Los Angeles, CA 90095, USA. Electronic address: TSeeman@mednet.ucla.edu.
Adam A SzpiroUniversity of Washington, Department of Biostatistics, Box 357232, Seattle, WA 98195, USA. Electronic address: aszpiro@uw.edu.
Joel D KaufmanUniversity of Washington, Departments of Environmental and Occupational Health Sciences and Epidemiology, Box 354695, Seattle, WA 98195, USA. Electronic address: joelk@uw.edu.
Ana Diez RouxDrexel University Dornsife School of Public Health, Urban Health Collaborative Nesbitt Hall 3215 Market Street Philadelphia, PA 19104, USA. Electronic address: avd37@drexel.edu.

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Sheela Sathyanarayana · 1995 to 2026
$42.5M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
UCLA OLDER AMERICANS INDEPENDENCE CENTERP30AG028748 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KARLAMANGLA, ARUN S · 2006 to 2017
$9.8M
Stress, Gene-Environment Interaction and Cardiovascular DiseaseR01HL101161 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DIEZ ROUX, ANA VICTORIA, NEEDHAM, BELINDA L. · 2010 to 2013
$4.1M
Socioeconimic Patterning of Inflammation and HemostasisR01HL076831 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DIEZ-ROUX, ANA V. · 2004 to 2007
$2.5M
Cigarette Smoke and Susceptibility to Influenza InfectionR01HL095163 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JASPERS, ILONA, NOAH, TERRY L · 2009 to 2013
$2.0M
Adjunctive Use of Apyrase to Fibrinolytic TherapyR44HL095169 · NHLBI · APT THERAPEUTICS, INC. · PI CHEN, RIDONG · 2012 to 2013
$1.3M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095166 · HC · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 1999 to 2001
$758k
Interaction of Air Pollution and Psychosocial Stress on Cardiovascular Disease.R00ES023498 · NIEHS · UNIVERSITY OF WASHINGTON · PI HAJAT, ANJUM · 2016 to 2018
$747k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095162 · HC · JOHNS HOPKINS UNIVERSITY · PI SZKLO, MOYSES A · 1999 to 2000
$694k
EPA RD838300NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL076831NHLBI NIH HHS R01 HL101161NIA NIH HHS P30 AG028748NIEHS NIH HHS P30 ES007033NIEHS NIH HHS R00 ES023498NIEHS NIH HHS R21 ES024894
6 · The paper itself

Abstract

backgroundCortisol, a stress hormone released by the activation of the hypothalamic-pituitary-adrenal (HPA) axis, is critical to the body's adaptive response to physiological and psychological stress. Cortisol has also been implicated in the health effects of air pollution through the activation of the sympathetic nervous system. This study evaluates the cross-sectional and longitudinal association between several air pollutants and salivary cortisol.

methodsWe used data from the Multi-Ethnic Study of Atherosclerosis (MESA), a cohort of 45-85 years old participants from six US cities. Salivary cortisol was evaluated at two time points between 2004 and 2006 and then again from 2010 to 2012. Cortisol samples were taken several times per day on two or three consecutive days. Particulate matter <2.5 μm in diameter (PM

resultsThe pooled cross-sectional results revealed largely null results with the exception of a 9.7% higher wake-up cortisol associated with a 10 ppb higher NO

conclusionsOur results suggest only a moderate association between traffic related air pollution and cortisol. Very few epidemiologic studies have examined the long-term impact of air pollution on the stress response systems, thus warranting further exploration of these findings.

Indexed as

AgedAged, 80 and overAir PollutionAtherosclerosisCross-Sectional StudiesHumansHydrocortisoneLongitudinal StudiesMiddle AgedSalivaUnited StatesHydrocortisoneCortisolHypothalamic-pituitary-adrenal axisNO(2)PM(2.5)Sympathetic nervous systemTraffic related air pollution

Identifiers

PMID31491811
PMCPMC6994173

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.