Evidence map›Paper›PMID 31491689›Full record

ArticleBehaviour research and therapy2019

Genetic influences on treatment-seeking for common mental health problems in the UK biobank.

Christopher Rayner, Jonathan R I Coleman, Kirstin L Purves, Rosa Cheesman, Christopher Hübel, Helena Gaspar, Kylie Glanville, Georgina Krebs, Genevieve Morneau-Vaillancourt, Gerome Breen and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behaviour research and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 3 countries.

Christopher RaynerKing's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK.
Jonathan R I ColemanKing's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK; NIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK.
Kirstin L PurvesKing's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK.
Rosa CheesmanKing's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK.
Christopher HübelKing's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK; NIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Helena GasparKing's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK.
Kylie GlanvilleKing's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK.
Georgina KrebsKing's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK.
Genevieve Morneau-VaillancourtResearch Unit on Child Psychosocial Maladjustment, Laval University, Canada.
Gerome BreenKing's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK; NIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK. Electronic address: gerome.breen@kcl.ac.uk.
Thalia C EleyKing's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK; NIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK. Electronic address: thalia.eley@kcl.ac.uk.
King's College London · GBResearch Unit on Children's Psychosocial Maladjustment · CA

Funding

Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MR/M021475/1
6 · The paper itself

Abstract

The majority of those who experience clinical anxiety and/or depressive symptoms in the population do not receive treatment. Studies investigating inequalities in treatment outcomes rarely consider that individuals respond differently to their experience of the environment. Much of our environment is under genetic influence, via our behaviour, whereby individuals actively select their experiences. If genes influence who seeks and receives treatment, selection bias will confound genomic studies of treatment response. Furthermore, if some individuals are at high genetic risk of needing but not commencing treatment, then greater efforts could be made to engage them. The role of common genetic variation on four lifetime treatment-seeking behaviours (treatment-seeking, treatment-receipt, self-help, self-medication with alcohol/drugs) was examined in participants of the UK Biobank (sample size range: 48,106 - 75,322). Treatment-related behaviours were only modestly heritable in these data. Nonetheless, genetic correlations reveal substantial genetic overlap between lifetime treatment-related behaviours and psychiatric disorders, symptoms and behavioural traits. To our knowledge, this is the first study to examine genetic influences on treatment-related behaviours. Further work is required to determine whether genetic factors could be used alongside clinical, social and demographic factors to identify at risk groups and inform strategies which target early intervention.

Indexed as

AdultAnxietyBiological Specimen BanksDepressionFemaleGene-Environment InteractionGenotypeHumansMaleMental DisordersMental HealthPatient Acceptance of Health CarePhenotypeRisk FactorsSelf-ManagementUnited KingdomAnxietyBehaviourDepressionGene-environment correlationGenetic correlationHeritabilityTreatment gapTreatment-seeking

Identifiers

PMID31491689
PMCPMC6873796
OpenAlexW2947475755

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.