Evidence map›Paper›PMID 31491445›Full record

ReviewAdvanced drug delivery reviews2019

Domesticating the foreign body response: Recent advances and applications.

Omid Veiseh, Arturo J Vegas

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advanced drug delivery reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

114 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Tissue-bioelectronics interfaces.Chemical Society reviews · 2026
    Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review

54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Omid VeisehDepartment of Bioengineering, Rice University, 6100 Main Street, Houston, TX 77030, USA. Electronic address: omid.veiseh@rice.edu.
Arturo J VegasDepartment of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, MA 02215, USA. Electronic address: ajvegas@bu.edu.

Funding

Synthesis and High-Throughput In Vivo Characterization of Alginate Encapsulation Materials for Long-Term IsletR01DK120459 · NIDDK · RICE UNIVERSITY · PI VEISEH, OMID · 2018 to 2021
$2.9M
Targeted immunomodulation of the diabetic islet microenvironmentDP2DK111913 · NIDDK · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI VEGAS, ARTURO · 2016 to 2016
$2.1M
NIDDK NIH HHS DP2 DK111913NIDDK NIH HHS R01 DK120459
6 · The paper itself

Abstract

The foreign body response is an immunological process that leads to the rejection of implanted devices and presents a fundamental challenge to their performance, durability, and therapeutic utility. Recent advances in materials development and device design are now providing strategies to overcome this immune-mediated reaction. Here, we briefly review our current mechanistic understanding of the foreign body response and highlight new anti-FBR technologies from this decade that have been applied successfully in biomedical applications relevant to implants, devices, and cell-based therapies. Further development of these important technologies promises to enable new therapies, diagnostics, and revolutionize the management of patient care for many intractable diseases.

Indexed as

Foreign-Body ReactionAnimalsEquipment and SuppliesHumansProstheses and ImplantsAlginateBiomaterialsCell encapsulationDevicesDiabetesFibrosisForeign body responseHydrogelImmunologyImmunomodulationImplantationZwitterionic

Identifiers

PMID31491445
PMCPMC6774350

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.