Evidence map›Paper›PMID 31491076›Full record

ArticleACS chemical neuroscience2019

Development of a PC12 Cell Based Assay for Screening Catechol-

Gongliang Zhang, Ingrid P Buchler, Michael DePasquale, Michael Wormald, Gangling Liao, Huijun Wei, James C Barrow, Gregory V Carr

Open access · greenAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Analytical methodologies for sensing catechol-Journal of pharmaceutical analysis · 2021
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Gongliang ZhangLieber Institute for Brain Development , Baltimore , Maryland 21205 , United States.
Ingrid P BuchlerLieber Institute for Brain Development , Baltimore , Maryland 21205 , United States.
Michael DePasqualeLieber Institute for Brain Development , Baltimore , Maryland 21205 , United States.
Michael WormaldLieber Institute for Brain Development , Baltimore , Maryland 21205 , United States.
Gangling LiaoLieber Institute for Brain Development , Baltimore , Maryland 21205 , United States.
Huijun WeiLieber Institute for Brain Development , Baltimore , Maryland 21205 , United States.
James C BarrowLieber Institute for Brain Development , Baltimore , Maryland 21205 , United States.
Gregory V CarrLieber Institute for Brain Development , Baltimore , Maryland 21205 , United States.ORCID 0000-0002-6091-6729
Johns Hopkins University · USLieber Institute for Brain Development · US

Funding

Drug discovery of COMT inhibitors to treat cognitive deficits in schizophreniaR01MH107126 · NIMH · LIEBER INSTITUTE, INC. · PI BARROW, JAMES · 2015 to 2019
$4.1M
NIMH NIH HHS R01 MH107126
6 · The paper itself

Abstract

The male rat adrenal pheochromocytoma cell-derived PC12 cell line can synthesize and release catecholamine neurotransmitters, and it has been widely used as a model system in cell biology and toxicology research. Catechol-

Indexed as

AnimalsCatechol O-Methyltransferase InhibitorsCell SurvivalDopamineDrug Evaluation, PreclinicalPC12 CellsRatsCatechol O-Methyltransferase InhibitorsDopaminecatechol-O-methyltransferasedopaminePC12 cells

Identifiers

PMID31491076
PMCPMC7032882
OpenAlexW2972186560

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.