ArticlePloS one2019
European hedgehogs (Erinaceus europaeus) as a natural reservoir of methicillin-resistant Staphylococcus aureus carrying mecC in Denmark.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Insectivores exhibit superior microbial network connectivity and elevated zoonotic risk by 2035 relative to rodents and bats.Science China. Life sciences · 2026Article
- Occurrence of third-generation cephalosporin-resistant Escherichia coli in European hedgehogs (Erinaceus europaeus) from a wildlife rescue centre in Lombardy, Northern Italy.Veterinary research communications · 2026Article
- The ESKAPE Challenge: Understanding Resistance and Exploring Alternative Treatments.Antibiotics (Basel, Switzerland) · 2026Review
- High Nasal Carriage of MRSA-mecC in Wild Rabbits in the Iberian Peninsula: a Wildlife Reservoir?Microbial ecology · 2026Article
- Zoonotic dermatophyteFrontiers in veterinary science · 2026Article
- Hidden carriers: multidrug-resistant bacteria in hedgehogs from a wildlife rescue centre.Frontiers in veterinary science · 2026Article
- Increased occurrence ofOne health (Amsterdam, Netherlands) · 2025Article
- Antimicrobial-ResistantAntibiotics (Basel, Switzerland) · 2025Article
- Antimicrobial Resistance Characterization of Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2025Article
- Methicillin-resistant and methicillin-susceptibleOne health (Amsterdam, Netherlands) · 2024Article
- The first full study of heavy metal(loid)s in western-European hedgehogs (Erinaceus europaeus) from Portugal.Environmental science and pollution research international · 2024Article
- A Review of the Occurrence of Metals and Xenobiotics in European Hedgehogs (Animals : an open access journal from MDPI · 2024Review
- Pesticides in the population of European hedgehogs (Frontiers in veterinary science · 2024Article
- Genomic epidemiology of mecC-carrying Staphylococcus aureus isolates from human clinical cases in New Zealand.Access microbiology · 2024Article
- High toxinogenic potential ofFrontiers in veterinary science · 2024Article
- Testing the Impact of Robotic Lawn Mowers on European Hedgehogs (Animals : an open access journal from MDPI · 2023Article
- Facing Danger: Exploring Personality and Reactions of European Hedgehogs (Animals : an open access journal from MDPI · 2023Article
- Clonal dissemination of successful emerging cloneOne health (Amsterdam, Netherlands) · 2023Article
- Comprehensive Approaches for the Search and Characterization of Staphylococcins.Microorganisms · 2023Article
- Characterisation of aPathogens (Basel, Switzerland) · 2023Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesA recent study from Sweden showed that European hedgehogs may constitute a reservoir for methicillin-resistant Staphylococcus aureus (MRSA), but this host-parasite relationship remains to be investigated in other countries. In this study, we therefore sought to: 1) determine the dissemination of MRSA in European hedgehogs throughout Denmark; 2) investigate determinants of MRSA carriage in hedgehogs; 3) determine the potential for zoonotic transmission of MRSA from hedgehogs to humans; and 4) characterise the detected MRSA on both a phenotypic and molecular level.
methodsNasal swabs were taken from 188 dead hedgehogs collected by volunteers throughout Denmark to determine the occurrence of MRSA. Additionally, 16 hedgehog rehabilitators were tested for potential zoonotic transmission of MRSA from hedgehogs to humans. The swabs were incubated in tryptic soy broth supplemented with 6.5% NaCl, followed by spread of 10 μl on Brilliance MRSA 2 agar. One presumptive MRSA colony from each plate was subcultured on 5% blood agar. All S. aureus subcultures were verified by a PCR assay detecting mecA, mecC, lukF-PV, scn, and spa, followed by spa typing.
resultsA total of 114 (61%) hedgehogs carried mecC-MRSA, whereas none carried mecA-MRSA. The detected mecC-MRSA belonged to two genetic lineages CC130 (spa-types: t528, t843, t1048, t3256, t3570, t6220, t17133) and CC1943 (spa-types: t978, t2345, t3391, t8835, t16868), 52% of which were spa-type t843 (CC130).The detection rate of mecC-MRSA in the hedgehogs was similar regardless of cause of death, sex, region and habitat type. None of the hedgehog rehabilitators carried MRSA.
conclusionsThis nationwide study confirms a high occurrence of mecC-MRSA in hedgehogs, which could serve as a natural reservoir for this specific type of MRSA. Furthermore, our study did not find signs of zoonotic transmission of mecC-MRSA to hedgehog rehabilitators.
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