ArticlePloS one2019
High production of carotenoids by the green microalga Asterarcys quadricellulare PUMCC 5.1.1 under optimized culture conditions.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 113 citations in OpenAlex.
- Advances in Sustainable Lutein Production: Sources, Technologies, and Functional Applications.Foods (Basel, Switzerland) · 2026Review
- Advances in Synthetic Strategies for Microalgal Carotenoid Enhancement and Emerging Applications.Antioxidants (Basel, Switzerland) · 2026Review
- Optimisation of physicochemical factors for enhanced astaxanthin accumulation in newly isolated freshwater green microalgae Desmodesmus sp. PLM2: insights from current analytical techniques.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Characterization of microalgal β-carotene and astaxanthin: exploring their health-promoting properties under the effect of salinity and light intensity.Biotechnology for biofuels and bioproducts · 2025Review
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- Toxicity of Moxifloxacin on the Growth, Photosynthesis, Antioxidant System, and Metabolism ofToxics · 2024Article
- Comparing Pharmacological Potential of Freshwater Microalgae Carotenoids Towards Antioxidant and Anti-proliferative Activity on Liver Cancer (HUH7) Cell Line.Applied biochemistry and biotechnology · 2024Article
- Comprehensive Analysis of Lutein and Loroxanthin inMolecules (Basel, Switzerland) · 2024Article
- The Application of Natural Carotenoids in Multiple Fields and Their Encapsulation Technology: A Review.Molecules (Basel, Switzerland) · 2024Review
- Synergistic effect of nitrate exposure and heatwaves on the growth, and metabolic activity of microalgae, Chlamydomonas reinhardtii, and Pseudokirchneriella subcapitata.Scientific reports · 2024Article
- Astaxanthin: Past, Present, and Future.Marine drugs · 2023Review
- Asterarcys quadricellulare (Chlorophyceae) protects H9c2 cardiomyoblasts from HMolecular and cellular biochemistry · 2023Article
- Valuable pigments from microalgae: phycobiliproteins, primary carotenoids, and fucoxanthin.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2023Review
- Microalgae Produce Antioxidant Molecules with Potential Preventive Effects on Mitochondrial Functions and Skeletal Muscular Oxidative Stress.Antioxidants (Basel, Switzerland) · 2023Review
- Natural Carotenoids: Recent Advances on Separation from Microbial Biomass and Methods of Analysis.Antioxidants (Basel, Switzerland) · 2023Review
- MicroalgaMolecules (Basel, Switzerland) · 2023Article
- Article
- Oxidative Stress- and Autophagy-Inducing Effects of PSI-LHCI fromBiotech (Basel (Switzerland)) · 2022Article
- Valorisation of algal biomass to value-added metabolites: emerging trends and opportunities.Phytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2022Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
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Abstract
Since carotenoids are important as natural colorants, antioxidants, neutraceutics and pharmaceutics, the aim of the present study was to find a new good source of these pigments. We hereby report a green microalga Asterarcys quadricellulare PUMCC 5.1.1 as a new and good producer of carotenoids. The organism produced 35±1.75 μg carotenoids mg-1 dry biomass during stationary phase in control cultures. The growth and carotenoids production by the test microalga were optimized by varying nutrient growth media, pH, nitrogen and phosphate source, salinity, light quality, intensity and duration. The optimized conditions for carotenoid production were: Bold basal (BB) medium with pH 8.5, containing with10 mM nitrate, 3.5 mM phosphate and 0.17 mM salinity and illuminated with blue light with 60 μmol m-2 s-1 photon flux light intensity. Cultivation of cultures in the above mentioned optimized conditions resulted in nearly 3.0 fold increase in carotenoid production compared to the control cultures grown in unmodified BB medium. Using HPTLC, four carotenoids have been identified as β-carotene, lutein, astaxanthin and canthaxanthin. Further, carotenoids were also separated and purified by flash chromatography and the amounts of purified carotenoids were determined by HPLC. The organism produced 47.0, 28.7, 15.5 and 14.0 μg β-carotene, lutein, astaxanthin and canthaxanthin mg-1 dry biomass, respectively, under optimized conditions. The amount of total carotenoids (118 μg mg-1 dry biomass) produced by Asterarcys quadricellulare PUMCC 5.1.1 under optimized culture conditions was significantly higher than control cultures. Thus, this microalgal strain is a promising candidate for carotenoid production at commercial level.
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