ArticlePloS one2019
Burden of influenza-associated respiratory hospitalizations in the Americas, 2010-2015.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- High Clinical Burden of Influenza Disease in Adults Aged ≥ 65 Years: Can We Do Better? A Systematic Literature Review.Advances in therapy · 2023Pooled it
- Effectiveness and Parental Acceptability of Social Networking Interventions for Promoting Seasonal Influenza Vaccination Among Young Children: Randomized Controlled Trial.Journal of medical Internet research · 2020Trial
- County-Level Influenza-Attributable Emergency Department Visits and Their Spatial Correlates in the United States: Cross-Sectional Observational Study.JMIR public health and surveillance · 2025Observational
- Influenza Vaccination in the Elderly in Three Cities in China: Current Status and Influencing Factors Under Different Funding Policies.Vaccines · 2025Article
- Economic Burden of Respiratory Viruses in Latin America and the Caribbean (LAC): A Scoping Literature Review.Influenza and other respiratory viruses · 2025Article
- Annual Estimation of Seasonal Influenza Burden in 6 South American Countries: A Retrospective Analysis of SARInet Surveillance Data to Inform Policies.The Journal of infectious diseases · 2025Article
- Influenza Vaccine-Averted Illness in Chile, Guyana, and Paraguay During 2013-2018: A Standardized Approach to Assess the Value of Vaccination.The Journal of infectious diseases · 2025Article
- Strengthening the Surveillance and Response to Public Health Events With a One Health Approach: A Perspective From 12 Countries in Latin America and the Caribbean.The Journal of infectious diseases · 2025Article
- Review
- Interim Effectiveness Estimates of 2024 Southern Hemisphere Influenza Vaccines in Preventing Influenza-Associated Hospitalization - REVELAC-i Network, Five South American Countries, March-July 2024.MMWR. Morbidity and mortality weekly report · 2024Article
- Impact of the COVID-19 Pandemic on Influenza Hospital Admissions and Deaths in Wales: Descriptive National Time Series Analysis.JMIR public health and surveillance · 2024Article
- Disease burden and high-risk populations for complications in patients with acute respiratory infections: a scoping review.Frontiers in medicine · 2024Article
- Influenza hospitalisations in Spain between the last influenza and COVID-19 pandemic (2009-2019).Epidemiology and infection · 2023Article
- Interim Effectiveness Estimates of 2023 Southern Hemisphere Influenza Vaccines in Preventing Influenza-Associated Hospitalizations - REVELAC-i Network, March-July 2023.MMWR. Morbidity and mortality weekly report · 2023Article
- End-of-season influenza vaccine effectiveness during the Southern Hemisphere 2022 influenza season - Chile, Paraguay, and Uruguay.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2023Article
- Knowledge, attitudes, and practices associated with frequent influenza vaccination among healthcare personnel in Peru, 2016─2018.Vaccine: X · 2023Article
- Impact of Influenza Vaccination on the Burden of Severe Influenza in the Elderly: Spain, 2017-2020.Vaccines · 2023Article
- Severity of influenza illness by seasonal influenza vaccination status among hospitalised patients in four South American countries, 2013-19: a surveillance-based cohort study.The Lancet. Infectious diseases · 2023Article
- Ferret model to mimic the sequential exposure of humans to historical H3N2 influenza viruses.Vaccine · 2023Article
- Article
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Authors and funding
42 authors.
Funding
Abstract
backgroundDespite having influenza vaccination policies and programs, countries in the Americas underutilize seasonal influenza vaccine, in part because of insufficient evidence about severe influenza burden. We aimed to estimate the annual burden of influenza-associated respiratory hospitalizations in the Americas.
methodsThirty-five countries in the Americas with national influenza surveillance were invited to provide monthly laboratory data and hospital discharges for respiratory illness (International Classification of Diseases 10th edition J codes 0-99) during 2010-2015. In three age-strata (<5, 5-64, and ≥65 years), we estimated the influenza-associated hospitalizations rate by multiplying the monthly number of respiratory hospitalizations by the monthly proportion of influenza-positive samples and dividing by the census population. We used random effects meta-analyses to pool age-group specific rates and extrapolated to countries that did not contribute data, using pooled rates stratified by age group and country characteristics found to be associated with rates.
resultsSixteen of 35 countries (46%) contributed primary data to the analyses, representing 79% of the America's population. The average pooled rate of influenza-associated respiratory hospitalization was 90/100,000 population (95% confidence interval 61-132) among children aged <5 years, 21/100,000 population (13-32) among persons aged 5-64 years, and 141/100,000 population (95-211) among persons aged ≥65 years. We estimated the average annual number of influenza-associated respiratory hospitalizations in the Americas to be 772,000 (95% credible interval 716,000-829,000).
conclusionsInfluenza-associated respiratory hospitalizations impose a heavy burden on health systems in the Americas. Countries in the Americas should use this information to justify investments in seasonal influenza vaccination-especially among young children and the elderly.
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