Evidence map›Paper›PMID 31490699›Full record

ArticleJournal of dental research2019

µ-Opioid Activity in Chronic TMD Pain Is Associated with COMT Polymorphism.

T D Nascimento, N Yang, D Salman, H Jassar, N Kaciroti, E Bellile, T Danciu, R Koeppe, C Stohler, J K Zubieta and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

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  6. [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
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  16. PJournal of pain research · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

T D NascimentoHeadache and Orofacial Pain Effort (H.O.P.E.), Biologic and Materials Sciences Department, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
N YangHeadache and Orofacial Pain Effort (H.O.P.E.), Biologic and Materials Sciences Department, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
D SalmanHeadache and Orofacial Pain Effort (H.O.P.E.), Biologic and Materials Sciences Department, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
H JassarHeadache and Orofacial Pain Effort (H.O.P.E.), Biologic and Materials Sciences Department, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
N KacirotiDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
E BellileDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
T DanciuDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
R KoeppePET Physics Section, Division of Nuclear Medicine, Radiology Department, University of Michigan, Ann Arbor, MI, USA.
C StohlerCollege of Dental Medicine, Columbia University, New York, NY, USA.
J K ZubietaDepartment of Psychiatry and Behavioral Health, Stony Brook University, Stony Brook, NY, USA.
V EllingrodCollege of Pharmacy, University of Michigan, Ann Arbor, MI, USA.
A F DaSilvaHeadache and Orofacial Pain Effort (H.O.P.E.), Biologic and Materials Sciences Department, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
University of Michigan–Ann Arbor · USColumbia University · USStony Brook University · US

Funding

Investigation and Modulation of the Central Mu-Opioid Mechanism in Migraine (in vivo)R01NS094413 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALEXANDRE DASILVA · 2015 to 2026
$4.3M
Investigation and Modulation of the Mu-Opioid Mechanism in Chronic TMD (in vivo)U01DE025633 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DASILVA, ALEXANDRE · 2016 to 2020
$2.4M
Brain as a Research and Therapeutic Target in Chronic TMDR56DE022637 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DASILVA, ALEXANDRE · 2013 to 2014
$773k
NIDCR NIH HHS R56 DE022637NIDCR NIH HHS U01 DE025633NINDS NIH HHS R01 NS094413
6 · The paper itself

Abstract

Clinicians have the dilemma of prescribing opioid or nonopioid analgesics to chronic pain patients; however, the impact of pain on our endogenous µ-opioid system and how our genetic profile (specifically catechol-O-methyltransferase [

Indexed as

AdultAnalgesics, OpioidCase-Control StudiesCatechol O-MethyltransferaseChronic PainFemaleGenotypeHumansMalePain ThresholdPolymorphism, Single NucleotidePositron-Emission TomographyReceptors, Opioid, muTemporomandibular Joint DisordersYoung AdultAnalgesics, OpioidCatechol O-MethyltransferaseCOMT protein, humanReceptors, Opioid, muchronic painfacial paingeneticsgenotypeneuroimagingpositron emission tomography

Identifiers

PMID31490699
PMCPMC6806132
OpenAlexW2972274177

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.