ArticleACS nano2019
Computational Image Analysis of Guided Acoustic Waves Enables Rheological Assessment of Sub-nanoliter Volumes.
Article in ACS nano, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- From Eyes to Cameras to Kinetics: Computer Vision for Chemical Process Monitoring.Accounts of chemical research · 2026Article
- Computer vision as a new paradigm for monitoring of solution and solid phase peptide synthesis.Chemical science · 2023Article
- Programmable Acoustic Holography using Medium-Sound-Speed Modulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Computer vision for non-contact monitoring of catalyst degradation and product formation kinetics.Chemical science · 2023Article
- Detection of Bacterial and Viral Pathogens Using Photonic Point-of-Care Devices.Diagnostics (Basel, Switzerland) · 2020Review
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Authors and funding
9 authors.
Funding
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Abstract
We present a method for the computational image analysis of high frequency guided sound waves based upon the measurement of optical interference fringes, produced at the air interface of a thin film of liquid. These acoustic actuations induce an affine deformation of the liquid, creating a lensing effect that can be readily observed using a simple imaging system. We exploit this effect to measure and analyze the spatiotemporal behavior of the thin liquid film as the acoustic wave interacts with it. We also show that, by investigating the dynamics of the relaxation processes of these deformations when actuation ceases, we are able to determine the liquid's viscosity using just a lens-free imaging system and a simple disposable biochip. Contrary to all other acoustic-based techniques in rheology, our measurements do not require monitoring of the wave parameters to obtain quantitative values for fluid viscosities, for sample volumes as low as 200 pL. We envisage that the proposed methods could enable high throughput, chip-based, reagent-free rheological studies within very small samples.
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