Evidence map›Paper›PMID 31490591›Full record

ArticleAngewandte Chemie (International ed. in English)2019

Enantioselective Iridium-Catalyzed Allylation of Acetylenic Ketones via 2-Propanol-Mediated Reductive Coupling of Allyl Acetate: C14-C23 of Pladienolide D.

Gilmar A Brito, Woo-Ok Jung, Minjin Yoo, Michael J Krische

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Electroreductive Olefin-Ketone Coupling.Journal of the American Chemical Society · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gilmar A BritoUniversity of Texas at Austin, Department of Chemistry, 105 E 24th St. (A5300), Austin, TX, 78712-1167, USA.
Woo-Ok JungUniversity of Texas at Austin, Department of Chemistry, 105 E 24th St. (A5300), Austin, TX, 78712-1167, USA.
Minjin YooUniversity of Texas at Austin, Department of Chemistry, 105 E 24th St. (A5300), Austin, TX, 78712-1167, USA.
Michael J KrischeUniversity of Texas at Austin, Department of Chemistry, 105 E 24th St. (A5300), Austin, TX, 78712-1167, USA.ORCID 0000-0001-8418-9709

Funding

Substituted Piperidine Formation via C-C Bond Forming Transfer HydrogenationR01GM069445 · NIGMS · UNIVERSITY OF TEXAS AUSTIN · PI KRISCHE, MICHAEL J · 2005 to 2024
$6.7M
Polyketides via Redox-Triggered Alcohol C-H Functionalization.R01GM093905 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI KRISCHE, MICHAEL J · 2011 to 2024
$4.5M
NIGMS NIH HHS R01 GM069445NIGMS NIH HHS R01 GM093905Welch Foundation F-0038
6 · The paper itself

Abstract

Highly enantioselective catalytic reductive coupling of allyl acetate with acetylenic ketones occurs in a chemoselective manner in the presence of aliphatic or aromatic ketones. This method was used to construct C14-C23 of pladienolide D in half the steps previously required.

Indexed as

2-PropanolAcetatesAlkynesAllyl CompoundsCatalysisEpoxy CompoundsHumansIridiumKetonesMacrolidesMolecular StructureStereoisomerism2-PropanolAcetatesAlkynesallyl acetateAllyl CompoundsEpoxy CompoundsIridiumKetonesMacrolidespladienolide Denantioselectivityiridiumketone allylationtransfer hydrogenationπ-allyl

Identifiers

PMID31490591
PMCPMC6917958

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.