ArticleAIDS (London, England)2019
A modeling framework to inform preexposure prophylaxis initiation and retention scale-up in the context of 'Getting to Zero' initiatives.
Article in AIDS (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prospects of HIV elimination among men who have sex with men: A systematic review of modeling studies.PLoS computational biology · 2026Pooled it
- A Review of Network Models for HIV Spread.Journal of acquired immune deficiency syndromes (1999) · 2025Pooled it
- Trial
- A Pilot Study of a Patient Navigation Intervention to Improve HIV Pre-exposure Prophylaxis Persistence Among Black/African American Men Who Have Sex With Men.Journal of acquired immune deficiency syndromes (1999) · 2022Trial
- Brief Report: Long-Acting Injectable PrEP Can Substantially Reduce HIV Incidence in Los Angeles County: A Simulation Study.Journal of acquired immune deficiency syndromes (1999) · 2026Article
- Incorporating social determinants of health into agent-based models of HIV transmission: methodological challenges and future directions.Frontiers in epidemiology · 2025Review
- Social network dynamics of tobacco smoking and alcohol use among persons involved with the criminal legal system (PCLS): A modeling study.International journal of alcohol and drug research · 2024Article
- Impact of post-incarceration care engagement interventions on HIV transmission among young Black men who have sex with men and their sexual partners: an agent-based network modeling study.Lancet regional health. Americas · 2023Article
- Characterizing the Impact of the COVID-19 Pandemic on HIV PrEP care: A Review and Synthesis of the Literature.AIDS and behavior · 2023Review
- DISTRIBUTED AGENT-BASED SIMULATION WITH REPAST4PY.Proceedings of the ... Winter Simulation Conference. Winter Simulation Conference · 2022Article
- Diagnosing PrEP Communication Self-Efficacy in a Community-Based Peer Leader Intervention for Black Sexual Minority Men.AIDS and behavior · 2022Article
- Ryan White programming that primarily supports clinical care falls short when core people needs are not met: further evidence from the medical monitoring project.AIDS (London, England) · 2022Article
- Stimulant use interventions may strengthen 'Getting to Zero' HIV elimination initiatives in Illinois: Insights from a modeling study.The International journal on drug policy · 2022Article
- Article
- Partnership dynamics in mathematical models and implications for representation of sexually transmitted infections: a review.Annals of epidemiology · 2021Review
- Loss to Follow-Up and Re-Engagement in HIV Pre-Exposure Prophylaxis Care in the United States, 2013-2019.AIDS patient care and STDs · 2021Article
- Projecting the number of new HIV infections to formulate the "Getting to Zero" strategy in Illinois, USA.Mathematical biosciences and engineering : MBE · 2021Article
- Identifying influential neighbors in social networks and venue affiliations among young MSM: a data science approach to predict HIV infection.AIDS (London, England) · 2021Article
- Added Benefits of Pre-Exposure Prophylaxis Use on HIV Incidence with Minimal Changes in Efficiency in the Context of High Treatment Engagement Among Men Who Have Sex with Men.AIDS patient care and STDs · 2020Article
- Projecting the impact of equity-based preexposure prophylaxis implementation on racial disparities in HIV incidence among MSM.AIDS (London, England) · 2020Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
OBJECTIVE(S): 'Getting to Zero' (GTZ) initiatives aim to eliminate new HIV infections over a projected time frame. Increased preexposure prophylaxis (PrEP) uptake among populations with the highest HIV incidence, such as young Black MSM, is necessary to accomplish this aim. Agent-based network models (ABNMs) can help guide policymakers on strategies to increase PrEP uptake.
designEffective PrEP implementation requires a model that incorporates the dynamics of interventions and dynamic feedbacks across multiple levels including virus, host, behavior, networks, and population. ABNMs are a powerful tool to incorporate these processes.
methodsAn ABNM, designed for and parameterized using data for young Black MSM in Illinois, was used to compare the impact of PrEP initiation and retention interventions on HIV incidence after 10 years, consistent with GTZ timelines. Initiation interventions selected individuals in serodiscordant partnerships, or in critical sexual network positions, and compared with a controlled setting where PrEP initiators were randomly selected. Retention interventions increased the mean duration of PrEP use. A combination intervention modeled concurrent increases in PrEP initiation and retention.
resultsSelecting HIV-negative individuals for PrEP initiation in serodiscordant partnerships resulted in the largest HIV incidence declines, relative to other interventions. For a given PrEP uptake level, distributing effort between increasing PrEP initiation and retention in combination was approximately as effective as increasing only one exclusively.
conclusionSimulation results indicate that expanded PrEP interventions alone may not accomplish GTZ goals within a decade, and integrated scale-up of PrEP, antiretroviral therapy, and other interventions might be necessary.
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