ArticlePediatric hematology and oncology2019
Quality of life in pre-adolescent children with sickle cell disease in Brazil.
Article in Pediatric hematology and oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Health-related quality of life in hemoglobinopathies: A systematic review from a global perspective.Frontiers in pediatrics · 2022Pooled it
- Health-related quality of life among patients with sickle cell disease in the hereditary blood disease center in Saudi Arabia.Medicine · 2026Article
- Clinical features and health-related quality of life in children with sickle cell disease in Khartoum, Sudan.BMC pediatrics · 2025Article
- Importance of neonatal screening: A case study of sickle cell disease and cystic fibrosis coexistence.World journal of clinical pediatrics · 2025Article
- Sickle cell disease and social determinants of health: A scoping review.Pediatric blood & cancer · 2023Article
- Impact of sickle cell disease on patients' daily lives, symptoms reported, and disease management strategies: Results from the international Sickle Cell World Assessment Survey (SWAY).American journal of hematology · 2021Article
- Quality of life assessments in a cohort of Mozambican children with sickle cell disease.The Pan African medical journal · 2020Article
- Self-Report for Assessment of Pain and Quality of Life in Children with Sickle Cell Anemia in a Developing Country.Journal of pain research · 2020Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Sickle cell disease (SCD) affects more than 13 million people and can have a significant impact on the quality of life (QoL) of those persons. We performed a cross-sectional study to evaluate the QoL in SCD children 8-12 years old enrolled from November 2014 to March 2016 in a large multicenter cohort study in Brazil. The PedsQL™ SCD Module was used to evaluate QoL in 412 children from six Brazilian health centers. The mean age of participants was 10.5 years and 193(46.7%) were women. The mean global score was 60.7, with a Cronbach´s alpha of 0.92. There were significant differences in socioeconomic demographics and treatments among participants at the six centers, but age, income, SCD genotype, and use of hydroxyurea did not significantly affect the QoL scores. After adjustment for all of these variables in a linear regression model, a significant difference was observed by site in global QoL score and the dimensions 'worry II'(β0 = 20.7,
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