Evidence map›Paper›PMID 31489962›Full record

ArticleCardiology journal2021

Genetic and environmental factors on heart rate, mean arterial pressure and carotid intima-media thickness: A longitudinal twin study.

Adam D Tarnoki, Laszlo Szalontai, Corrado Fagnani, David L Tarnoki, Pierleone Lucatelli, Pal Maurovich-Horvat, Adam L Jermendy, Attila Kovacs, Andrea Agnes Molnar, Erika Godor and 14 more

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Adam D TarnokiDepartment of Radiology, Semmelweis University, 78/a Ulloi street, H-1082 Budapest, Hungary.
Laszlo SzalontaiDepartment of Radiology, Semmelweis University, 78/a Ulloi street, H-1082 Budapest, Hungary. laszlo.szalontai.med@gmail.com.
Corrado FagnaniItalian Twin Registry, Centre for Behavioural Sciences and Mental Health; Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
David L TarnokiDepartment of Radiology, Semmelweis University, 78/a Ulloi street, H-1082 Budapest, Hungary.
Pierleone LucatelliVascular and Interventional Radiology Unit, Department of Radiological, Oncological and Anatomo-Pathological Sciences, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy.
Pal Maurovich-HorvatMTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 18 Hataror street, 1122 Budapest, Hungary.
Adam L JermendyMTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 18 Hataror street, 1122 Budapest, Hungary.
Attila KovacsMTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 18 Hataror street, 1122 Budapest, Hungary.
Andrea Agnes MolnarMTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 18 Hataror street, 1122 Budapest, Hungary.
Erika GodorDepartment of Radiology, Semmelweis University, 78/a Ulloi street, H-1082 Budapest, Hungary.
Bence FejerDepartment of Radiology, Semmelweis University, 78/a Ulloi street, H-1082 Budapest, Hungary.
Anita HernyesDepartment of Radiology, Semmelweis University, 78/a Ulloi street, H-1082 Budapest, Hungary.
Carlo CirelliVascular and Interventional Radiology Unit, Department of Radiological, Oncological and Anatomo-Pathological Sciences, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy.
Fabrizio FanelliVascular and Interventional Radiology Unit, Department of Radiological, Oncological and Anatomo-Pathological Sciences, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy.
Filippo FarinaDepartment of Neurosciences, University of Padua School of Medicine, Via Giustiniani 5, 35128 Padova, Italy.
Claudio BaracchiniDepartment of Neurosciences, University of Padua School of Medicine, Via Giustiniani 5, 35128 Padova, Italy.
Giorgio MeneghettiDepartment of Neurosciences, University of Padua School of Medicine, Via Giustiniani 5, 35128 Padova, Italy.
Anna V GyarmathyJohns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, MD 21205 Baltimore, United States.
Gyorgy Jermendy3rd Department of Internal Medicine, Bajcsy Zsilinszky Hospital, 89-91 Maglódi street, 1106 Budapest, Hungary.
Bela MerkelyMTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 18 Hataror street, 1122 Budapest, Hungary.
Giacomo PucciUniversità di Perugia, Unità di Medicina Interna, Ospedale, Viale Tristano di Joannuccio 1, 05100 Terni, Italy.
Giuseppe SchillaciUniversità di Perugia, Unità di Medicina Interna, Ospedale, Viale Tristano di Joannuccio 1, 05100 Terni, Italy.
Maria A StaziItalian Twin Registry, Centre for Behavioural Sciences and Mental Health; Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
Emanuela MeddaItalian Twin Registry, Centre for Behavioural Sciences and Mental Health; Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHeart rate (HR), mean arterial pressure (MAP) and carotid intima-media thickness (cIMT) are moderately heritable cardiovascular traits, but the environmental effects on the longitudinal change of their heritability have never been investigated.

methods368 Italian and Hungarian twins (107 monozygotic, 77 dizygotic) underwent oscillometric measurement and B-mode sonography of bilateral carotid arteries in 2009/2010 and 2014. Within- -individual/cross-study wave, cross-twin/within-study wave and cross-twin/cross-study wave correlations were estimated, and bivariate Cholesky models were fitted to decompose the total variance at each wave and covariance between study waves into additive genetic, shared and unique environmental components.

resultsFor each trait, a moderate longitudinal stability was observed, with within-individual/crosswave correlations of 0.42 (95% CI: 0.33-0.51) for HR, 0.34 (95% CI: 0.24-0.43) for MAP, and 0.23 (95% CI: 0.12-0.33) for cIMT. Cross-twin/cross-wave correlations in monozygotic pairs were all significant and substantially higher than the corresponding dizygotic correlations. Genetic continuity was the main source of longitudinal stability, with across-time genetic correlations of 0.52 (95% CI: 0.29-0.71) for HR, 0.56 (95% CI: 0.31-0.81) for MAP, and 0.36 (95% CI: 0.07-0.64) for cIMT. Overlapping genetic factors explained respectively 57%, 77%, and 68% of the longitudinal covariance of the HR, MAP and cIMT traits.

conclusionsGenetic factors have a substantial role in the longitudinal change of HR, MAP and cIMT; however, the influence of unique environmental factors remains relevant. Further studies should better elucidate whether epigenetic mechanisms have a role in influencing the stability of the investigated traits over time.

Indexed as

Arterial PressureCarotid Intima-Media ThicknessHeart RateHumansRisk FactorsTwinscardiovascular arterial stiffnessepigeneticsgenetics

Identifiers

PMID31489962
PMCPMC8169182

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.