Evidence map›Paper›PMID 31489955›Full record

ArticleJournal of cardiovascular development and disease2019

Arterial Structural and Functional Characteristics at End of Early Childhood and Beginning of Adulthood: Impact of Body Size Gain during Early, Intermediate, Late and Global Growth.

Juan M Castro, Victoria García-Espinosa, Agustina Zinoveev, Mariana Marin, Cecilia Severi, Pedro Chiesa, Daniel Bia, Yanina Zócalo

Abstract read
In one paragraph

Article in Journal of cardiovascular development and disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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  12. Is There a Link Between Nutrition, Genetics, and Cardiovascular Disease?Journal of cardiovascular development and disease · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Juan M CastroDepartamento de Fisiología, Facultad de Medicina, Centro Universitario de Investigación, Innovación y Diagnóstico Arterial, Universidad de la República, General Flores 2125, 11800 Montevideo, Uruguay.ORCID 0000-0001-6083-5593
Victoria García-EspinosaDepartamento de Fisiología, Facultad de Medicina, Centro Universitario de Investigación, Innovación y Diagnóstico Arterial, Universidad de la República, General Flores 2125, 11800 Montevideo, Uruguay.
Agustina ZinoveevDepartamento de Fisiología, Facultad de Medicina, Centro Universitario de Investigación, Innovación y Diagnóstico Arterial, Universidad de la República, General Flores 2125, 11800 Montevideo, Uruguay.
Mariana MarinDepartamento de Fisiología, Facultad de Medicina, Centro Universitario de Investigación, Innovación y Diagnóstico Arterial, Universidad de la República, General Flores 2125, 11800 Montevideo, Uruguay.
Cecilia SeveriDepartamento de Medicina Preventiva y Social, Instituto de Higiene, Facultad de Medicina, Universidad de la República, Alfredo Navarro 3051, 11600 Montevideo, Uruguay.
Pedro ChiesaServicio de Cardiología Pediátrica, Centro Hospitalario Pereira-Rossell, ASSE-Facultad de Medicina, Universidad de la República, Bulevar Artigas 1550, 11600 Montevideo, Uruguay.
Daniel BiaDepartamento de Fisiología, Facultad de Medicina, Centro Universitario de Investigación, Innovación y Diagnóstico Arterial, Universidad de la República, General Flores 2125, 11800 Montevideo, Uruguay.ORCID 0000-0001-7160-7166
Yanina ZócaloDepartamento de Fisiología, Facultad de Medicina, Centro Universitario de Investigación, Innovación y Diagnóstico Arterial, Universidad de la República, General Flores 2125, 11800 Montevideo, Uruguay. yana@fmed.edu.uy.

Funding

Agencia Nacional de Investigación e Innovación PRSCT-008-020, FSPI-x-2015-1-108484
6 · The paper itself

Abstract

An association between nutritional characteristics in theearlylife stages and the state of the cardiovascular (CV) system in early childhood itself and/or at the beginning of adulthood has been postulated. It is still controversial whether changes in weight, height and/or body mass index (BMI) during childhood or adolescence are independently associated with hemodynamics and/or arterial properties in early childhood and adulthood.

aimsFirst, to evaluate and compare the strength of association between CVproperties (at 6 and 18 years (y)) and (a) anthropometric data at specific growth stages (e.g., birth, 6 y, 18 y) and (b) anthropometric changes during early (0-2 y), intermediate (0-6 y), late (6-18 y) and global (0-18 y) growth. Second, to determine whether the associations between CVproperties and growth-related body changes depend on size at birth and/or at the time of CVstudy. Third, to analyze the capacity of growth-related body size changes to explain hemodynamic and arterial properties in early childhood and adulthood before and after adjusting for exposure to CV risk factors. Anthropometric, hemodynamic (central, peripheral) and arterial parameters (structural, functional; elastic, transitional and muscular arteries) were assessed in two cohorts (children,

resultsBody-size changes in infancy (0-2 y) and childhood (0-6 y) showed similar strength of association with CV properties at 6 y. Conversely, 0-6, 6-18 or 0-18 ychanges were not associated with CV parameters at 18 y. The association between CV properties at 6 yand body-size changes during growth showed: equal or greater strength than the observed for body-size at birth, and lower strength compared to that obtained for current z-BMI. Conversely, only z-BMI at 18 y showed associations with CV z-scores at 18 y. Body size at birth showed almost no association with CVproperties at 6 or 18 y.

conclusioncurrent z-BMI showed the greatest capacity to explain variations in CV properties at 6 and 18 y. Variations in some CV parameters were mainly explained by growth-related anthropometric changes and/or by their interaction with current z-BMI. Body size at birth showed almost no association with arterial properties at 6 or 18 y.

Indexed as

adolescentsarterial stiffnessbirth weightblood pressurebody-size trajectoriescardio-metabolic healthchildrengrowthintima-media thickness

Identifiers

PMID31489955
PMCPMC6787690

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.