ArticleInternational journal of molecular sciences2019
Ring Formation and Hydration Effects in Electron Attachment to Misonidazole.
Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 14 citations in OpenAlex.
- Nitro-Group π System Drives the Interaction of RRx-001 with Electrons in Solution.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Electron attachment to fluorodeoxyglucose: Dissociation dynamics in a molecule of near-zero electron affinity.The Journal of chemical physics · 2022Article
- Low-Energy Electron Induced Reactions in Metronidazole at Different Solvation Conditions.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Electron Attachment Studies with the Potential Radiosensitizer 2-Nitrofuran.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 3 countries.
Funding
Abstract
We study the reactivity of misonidazole with low-energy electrons in a water environment combining experiment and theoretical modelling. The environment is modelled by sequential hydration of misonidazole clusters in vacuum. The well-defined experimental conditions enable computational modeling of the observed reactions. While the NO 2 - dissociative electron attachment channel is suppressed, as also observed previously for other molecules, the OH - channel remains open. Such behavior is enabled by the high hydration energy of OH - and ring formation in the neutral radical co-fragment. These observations help to understand the mechanism of bio-reductive drug action. Electron-induced formation of covalent bonds is then important not only for biological processes but may find applications also in technology.
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Registered trials
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