Evidence map›Paper›PMID 31489921›Full record

ArticleInternational journal of molecular sciences2019

Contribution of Corticotropin-Releasing Factor Receptor 1 (CRF1) to Serotonin Receptor 5-HT

Guangchen Ji, Volker Neugebauer

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Guangchen JiDepartment of Pharmacology and Neuroscience, Texas Tech University Health Sciences Center, Lubbock, TX 79424, USA.
Volker NeugebauerDepartment of Pharmacology and Neuroscience, Texas Tech University Health Sciences Center, Lubbock, TX 79424, USA. volker.neugebauer@ttuhsc.edu.
Texas Tech University · USTexas Tech University Health Sciences Center · US

Funding

PAIN, NOCICEPTION, AND THE AMYGDALAR01NS038261 · NINDS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI Volker Neugebauer, Igor Ponomarev · 1999 to 2026
$8.7M
Stress-induced descending facilitation from amygdala kappa opioid receptors in functional painR01NS106902 · NINDS · UNIVERSITY OF ARIZONA · PI NEUGEBAUER, VOLKER, PORRECA, FRANK · 2018 to 2022
$2.7M
NIH HHS NS038261NIH HHS NS081121NIH HHS NS106902NINDS NIH HHS R01 NS038261
6 · The paper itself

Abstract

The amygdala plays a key role in emotional-affective aspects of pain and in pain modulation. The central nucleus (CeA) serves major amygdala output functions related to emotional-affective behaviors and pain modulation. Our previous studies implicated the corticotropin-releasing factor (CRF) system in amygdala plasticity and pain behaviors in an arthritis model. We also showed that serotonin (5-HT) receptor subtype 5-HT

Indexed as

AmygdalaAnimalsCRF Receptor, Type 1Disease Models, AnimalGene Knockdown TechniquesMaleNeuralgiaNeuronsRatsReceptors, Corticotropin-Releasing HormoneReceptor, Serotonin, 5-HT2CSerotonin 5-HT2 Receptor AntagonistsCRF Receptor, Type 1Receptors, Corticotropin-Releasing HormoneReceptor, Serotonin, 5-HT2CSerotonin 5-HT2 Receptor Antagonistsamygdala neuronsCRFhyperactivityneuropathic painserotoninshort hairpin RNA (shRNA)

Identifiers

PMID31489921
PMCPMC6770811
OpenAlexW2972014858

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.