Evidence map›Paper›PMID 31489598›Full record

ReviewAging clinical and experimental research2020

Is frailty a prognostic factor for adverse outcomes in older patients with acute coronary syndrome?

Shaomin Zhang, Hongdao Meng, Qian Chen, Xiaoling Wang, Jiatong Zou, Qiukui Hao, Ming Yang, Jinhui Wu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Aging clinical and experimental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  7. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Shaomin ZhangThe Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, China.
Hongdao MengUniversity of South Florida, Tampa, FL, USA.
Qian ChenThe Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, China.
Xiaoling WangThe Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, China.
Jiatong ZouThe Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, China.
Qiukui HaoThe Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, China.
Ming YangThe Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, China. yangmier@gmail.com.
Jinhui WuThe Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, China. wujinhui@scu.edu.cn.ORCID http://orcid.org/0000-0003-0763-7728

Funding

National Key R&D Program of China (No. 2018YFC2002100National Key R&D Program of China No. 2018YFC2002103
6 · The paper itself

Abstract

backgroundThere is very limited guidance in regard to how biological age should be estimated and how different comorbidity conditions influence the benefit-risk ration of interventions. Frailty is an important health-related problem in patients, especially in older adults. It is a reflection of biologic rather than chronologic age; frailty may explain why there remains substantial heterogeneity in clinical outcomes within the older patients' population.

aimsWe aimed to review the prognostic value of frailty for adverse outcomes in older patients with acute coronary syndrome (ACS).

methodsStudies published until December 31, 2018, identified by systematic Medline, Embase, and Cochrane Controlled Register of Trials (CENTRAL) searches were reviewed for the association between frailty and mortality in older patients with ACS. We used the Newcastle-Ottawa Quality Assessment Scale to assess the quality of the included studies. We extracted the information of hazard ratios (HR) and odds ratios (OR) with accompanying 95% confidence intervals (CI), and P values of multivariable analysis. Heterogeneity across studies was determined using the Cochran Q value by Review Manager 5.3.

resultsA total of 11 articles involving 7212 patients were included in this meta-analysis. Two studies (Sujino, Y 2015 and Alonso, S.GL 2016; n = 264) reported that frailty was significantly associated with in-hospital mortality in patients with ACS (range of reported OR between 6.38 and 12.0). We performed a subgroup analysis of the other nine studies based on differences in the follow-up time. Pooled meta-analysis demonstrates that frailty was associated with short-term, medium-term, and long-term mortality (HR = 3.67, 4.09, 1.66). There was no association between frailty and bleeding in older patients with ACS.

conclusionsFrailty measured by Canadian Study of Health and Aging Clinical Frailty Scale (CSHA-CFS), the Edmonton Frail Scale (EFS), Fried score, Green scores, frailty instrument from the Survey of Health, Ageing and Retirement in Europe (SHARE-FI) index, and FRAIL (Fatigue, Resistance, Ambulation, Illnesses, Loss of weight) scale, leads to significantly higher mortality rates in older patients with ACS.

Indexed as

Acute Coronary SyndromeFrail ElderlyFrailtyAgedCanadaEuropeHumansPrognosisAcute coronary syndromeFrailtyMortality

Identifiers

PMID31489598

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.