ReviewSingapore medical journal2020
Patient-centred and not disease-focused: a review of guidelines and multimorbidity.
Review in Singapore medical journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Nurse-Led Interventions to Improve Health, Adherence, and Functional Outcomes in Adults and Older Adults With Multimorbidity: A Systematic Review of Randomized and Quasiexperimental Studies.Journal of nursing management · 2025Pooled it
- Prevalence and Co-prevalence of Comorbidities among Patients with Type 2 Diabetes Mellitus in the MENA Region: A Systematic Review.Current diabetes reviews · 2024Pooled it
- A Systematic Review of the Patterns of Associative Multimorbidity in Asia.BioMed research international · 2021Pooled it
- Shared Experiences and Care Improvement Priorities for Multimorbidity Management: An Experience-Based Co-Design Study.Learning health systems · 2026Article
- From guidelines to practice: general practitioners' consensus on indicators for managing selected multimorbidity in primary care in Western Australia.Family practice · 2026Article
- Drug class duplication patterns among South African middle-aged adults: findings from a medicine claims database.International journal of clinical pharmacy · 2026Article
- Time toxicity in chronic disease comorbidity care: A concept analysis using Walker and Avant's approach.International journal of nursing sciences · 2026Article
- Deep learning predicts onset acceleration of 38 age-associated diseases from blood and body composition biomarkers in the UK Biobank.GeroScience · 2026Article
- Association between physical multimorbidity in middle adulthood and mortality: findings from two large cohort studies in Japan.BMC public health · 2025Article
- Clinically sound and person centred: streamlining clinical decision support guidance for multiple long-term condition care.BMJ global health · 2024Article
- A qualitative study on general practitioners' perspectives on late-life depression in Singapore-part I: patient presentations and behaviours.The Lancet regional health. Western Pacific · 2024Article
- A qualitative study of negative sociocultural experiences of accessing primary health care services among Africans from refugee backgrounds in Australia: implications for organisational health literacy.BMC primary care · 2024Article
- Prevention and Management of Multimorbidity in Southeast Asia: A Narrative Review.Public health challenges · 2024Review
- General practitioners' assessment and management of chronic kidney disease in older patients- a mixed methods study.BMC primary care · 2024Article
- Study protocol for Care cOORDInatioN And sympTom managEment (COORDINATE) programme: a feasibility study.BMJ open · 2023Article
- Cross-sectional study assessing health outcome priorities of older adults with multimorbidity at a primary care setting in Singapore.BMJ open · 2023Article
- Primary care utilisation, adherence to guideline-based pharmacotherapy and continuity of care in primary care patients with chronic diseases and multimorbidity - a cross-sectional study.BMC primary care · 2023Article
- Type 2 Diabetes Mellitus and Asthma: Pathomechanisms of Their Association and Clinical Implications.Cureus · 2023Review
- Living with multiple chronic conditions: How we achieve holistic care and optimize health outcomes.Journal of advanced nursing · 2023Article
- Exploring human biology with N-of-1 clinical trials.Cambridge prisms. Precision medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSingle-disease clinical practice guidelines (CPGs) are not designed to consider patients with multiple chronic conditions, or multimorbidity. Applying multiple CPGs to a single patient may create an overwhelming treatment burden resulting in poor adherence and clinical outcomes. No studies on the cumulative treatment burden from multiple CPGs have been done in Singapore. We described the treatment burden on a hypothetical patient with six chronic conditions when multiple CPGs were applied, and appraised each CPG with respect to the patient-centred care of older adults with multimorbidity.
methodsA treatment plan was developed for a hypothetical 72-year-old woman with asthma, depression, diabetes mellitus, dyslipidaemia, hypertension and osteoarthritis according to the latest CPG recommendations. Treatment burden was quantified in terms of time spent, cost, and the number of appointments and medications. Each CPG was appraised with respect to the care of older adults, patients with multimorbidity and patient-centred care.
resultsFollowing the CPGs strictly, an average of about two hours was spent daily taking 14 different medications and following 21 non-pharmacological recommendations. Her out-of-pocket payment was SGD 104.42 monthly despite a near 90% subsidy on healthcare bills. Patient-centred care of older adults with multimorbidity was inadequately addressed in all six CPGs.
conclusionWhen six CPGs were cumulatively followed, the treatment burden was time-consuming, costly and disruptive. Patients' goals and preferences must guide prioritisation of care such that treatment burden remains minimally disruptive to their lives. Developing future CPGs to deliver patient-centred rather than disease-focused care will be crucial to the management of multimorbidity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.