Evidence map›Paper›PMID 31489429›Full record

ArticleSingapore medical journal2020

Outcomes following selective fetoscopic laser ablation for twin-to-twin transfusion syndrome: a single-centre experience.

Michelle Loh, Anju Bhatia, Kai Lit Tan, Edwin Thia, George Seow Heong Yeo

Open access · diamondAbstract readTwin Study
In one paragraph

Article in Singapore medical journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Michelle LohDepartment of Obstetrics and Gynaecology, KK Women's and Children's Hospital, Singapore.
Anju BhatiaDepartment of Maternal Fetal Medicine, KK Women's and Children's Hospital, Singapore.
Kai Lit TanDepartment of Maternal Fetal Medicine, KK Women's and Children's Hospital, Singapore.
Edwin ThiaDepartment of Maternal Fetal Medicine, KK Women's and Children's Hospital, Singapore.
George Seow Heong YeoDepartment of Maternal Fetal Medicine, KK Women's and Children's Hospital, Singapore.
KK Women's and Children's Hospital · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionFetoscopic laser photocoagulation (FLP), a treatment option for twin-to-twin transfusion syndrome (TTTS) in monochorionic twin pregnancies, is currently the treatment of choice at our centre. We previously reported on our experience of FLP from June 2011 to March 2014. This paper audits our fetal surgery performance since then.

methods15 consecutive patients who underwent FLP for Stage II-III TTTS before 26 weeks of gestation from June 2011 to January 2017 were retrospectively reviewed, consisting of five cases from our initial experience and ten subsequent cases. Perioperative, perinatal and neonatal outcomes were analysed.

resultsOf 15 pregnancies, 10 (66.7%) and 5 (33.3%) were for Stage II and III TTTS respectively, with FLP performed at an earlier Quintero stage in the later cohort. Overall mean gestational ages at presentation, laser and delivery were comparable between the cohorts at 19.7 (15.4-24.3) weeks, 20.3 (16.3-25.0) weeks and 31.2 (27.6-37.0) weeks, respectively. 2 (13.3%) cases had intra-amniotic bleeding and 1 (6.7%) had iatrogenic septostomy. 1 (6.7%) case had persistent TTTS requiring repeat FLP, and another (6.7%) had preterm premature rupture of membranes at seven weeks post procedure. The overall perinatal survival rate was 21 (75.0%) out of 28 infants. One mother underwent termination of pregnancy for social reasons at 1.4 weeks post procedure. Double survival occurred in 8 (57.1%) out of 14 pregnancies, while 13 (92.9%) had at least one survivor.

conclusionFLP requires a highly specialised team and tertiary neonatal facility. Continual training improves maternal and perinatal outcomes, ensuring comparable standards with international centres.

Indexed as

FemaleFetofetal TransfusionGestational AgeHumansLaser TherapyPregnancyPregnancy, TwinRetrospective StudiesSingaporeSurvival Ratefetoscopic laser photocoagulationmonochorionictwin-to-twin transfusion syndrome

Identifiers

PMID31489429
PMCPMC7930304
OpenAlexW2971780003

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.