ArticleScience advances2019
Cushing's syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity.
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Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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48citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
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Who cites it
48 citing papers in PubMed, 67 citations in OpenAlex.
- Substrate-Derived Peptides for Selective Covalent Inhibition of Protein Tyrosine Kinases.ACS chemical biology · 2026Article
- DT-TRAP enables accurate target recognition via simplified dosing and low-temperature incubation.Journal of pharmaceutical analysis · 2026Article
- Substrate-derived peptides for selective covalent inhibition of protein tyrosine kinases.bioRxiv : the preprint server for biology · 2026Article
- A PKA-selective inhibitor captures an open but more ordered conformation of the PKA catalytic subunit.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The COX2-PGEbioRxiv : the preprint server for biology · 2026Article
- Conformational Dynamics and Allostery in the cAMP-Protein Kinase A Signalosome.Advances in experimental medicine and biology · 2026Review
- cAMP/PKA signaling in endocrine hypertension: genetic mechanisms and pathophysiological insights.Frontiers in endocrinology · 2026Review
- Review
- Allosteric binding cooperativity in kinases signaling, signalopathies, and drug development.Current opinion in structural biology · 2025Review
- Uncovering the molecular basis of kinase activity and substrate recognition with phospho-PCA.bioRxiv : the preprint server for biology · 2025Article
- The evolution of AKAPs and emergence of PKA isotype selective anchoring determinants.The Journal of biological chemistry · 2025Article
- Article
- A mutation in the PRKAR1B gene drives pathological mechanisms of neurodegeneration across species.Brain : a journal of neurology · 2024Article
- Rare correlation of somatic PRKACA mutations with pregnancy-associated aldosterone- and cortisol-producing adenomas: a case report and literature review.BMC endocrine disorders · 2024Review
- Article
- Recruitment of BAG2 to DNAJ-PKAc scaffolds promotes cell survival and resistance to drug-induced apoptosis in fibrolamellar carcinoma.Cell reports · 2024Article
- Discovery of a Cushing's syndrome protein kinase A mutant that biases signaling through type I AKAPs.Science advances · 2024Article
- Discovery and Synthesis of a Naturally Derived Protein Kinase Inhibitor that Selectively Inhibits Distinct Classes of Serine/Threonine Kinases.Journal of natural products · 2023Article
- Protein Kinase Structure and Dynamics: Role of the αC-β4 Loop.bioRxiv : the preprint server for biology · 2023Article
- AI-designed NMR spectroscopy RF pulses for fast acquisition at high and ultra-high magnetic fields.Nature communications · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 4 countries.
Caitlin WalkerDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0003-0977-8276
Yingjie WangDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0001-9800-8163
Cristina OlivieriDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0001-6957-6743
Adak KaramafroozDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-6190-341X
Jordan CasbyDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-5601-3906
Kerstin BathonInstitute for Pharmacology and Toxicology, University of Würzburg, 97078 Würzburg, Germany.
Davide CalebiroInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham B15 2TT, UK.ORCID 0000-0002-3811-1553
Jiali GaoDepartment of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0003-0106-7154
David A BernlohrDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Susan S TaylorDepartments of Chemistry and Biochemistry and Pharmacology, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-7702-6108
Gianluigi VegliaDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-2795-6964
University of Minnesota · USUniversity of Birmingham · GBUniversity of California San Diego · USUniversity of Würzburg · DE
Funding
Lessons Learned from PKA: Assembly of Dynamic Macromolecular SwitchesR35GM130389 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUSAN S. TAYLOR · 2019 to 2026
$5.7MMapping Allosteric Cooperativity in Protein KinasesR01GM100310 · NIGMS · UNIVERSITY OF MINNESOTA · PI VEGLIA, GIANLUIGI · 2012 to 2019
$4.3MConsole Upgrade for a 600 MHz NMR SpectrometerS10OD021536 · OD · UNIVERSITY OF MINNESOTA · PI VEGLIA, GIANLUIGI · 2016 to 2016
$850kNIGMS NIH HHS R01 GM100310NIGMS NIH HHS R35 GM130389NIH HHS S10 OD021536
Abstract
Genetic alterations in the
Indexed as
Adrenocortical AdenomaAllosteric RegulationCatalytic DomainCushing SyndromeCyclic AMP-Dependent Protein Kinase Catalytic SubunitsCyclic AMP-Dependent Protein KinasesHumansHydrocortisoneMutationSubstrate SpecificityCyclic AMP-Dependent Protein Kinase Catalytic SubunitsCyclic AMP-Dependent Protein KinasesHydrocortisone
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.