Evidence map›Paper›PMID 31489370›Full record

ArticleScience advances2019

Evolutionary adaptation in fucosyllactose uptake systems supports bifidobacteria-infant symbiosis.

Mikiyasu Sakanaka, Morten Ejby Hansen, Aina Gotoh, Toshihiko Katoh, Keisuke Yoshida, Toshitaka Odamaki, Hiroyuki Yachi, Yuta Sugiyama, Shin Kurihara, Junko Hirose and 8 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 176 citations in OpenAlex.

  1. Global biogeography ofGut microbes · 2026
    Review
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Review
  7. Occurrence and applications of CRISPR-Cas systems in bifidobacteria.Applied and environmental microbiology · 2026
    Review
  8. Review
  9. Infant-derivedFrontiers in nutrition · 2026
    Article
  10. Metabolic interactions and growth dynamics ofFrontiers in microbiology · 2026
    Article
  11. Article
  12. Gut microbes · 2025
    Article
  13. 3'-Sialyllactose andGut microbes · 2025
    Article
  14. Article
  15. Article
  16. Observational
  17. Article
  18. Article
  19. Gene-trait matching amongFrontiers in microbiology · 2025
    Article
  20. Genetic analysis of a β-1,3/1,4-glucan utilization gene cluster inBioscience of microbiota, food and health · 2025
    Article

45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 2 countries.

Mikiyasu SakanakaFaculty of Bioresources and Environmental Sciences, Ishikawa Prefectural University, Nonoichi, Ishikawa 921-8836, Japan.ORCID 0000-0002-4223-0926
Morten Ejby HansenDepartment of Biotechnology and Bioengineering, Technical University of Denmark, Søltofts Plads, DK-2800 Kgs. Lyngby, Denmark.ORCID 0000-0003-2099-3591
Aina GotohGraduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan.
Toshihiko KatohGraduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan.
Keisuke YoshidaNext Generation Science Institute, Morinaga Milk Industry Co. Ltd., Zama, Kanagawa 252-8583, Japan.ORCID 0000-0003-4903-7608
Toshitaka OdamakiNext Generation Science Institute, Morinaga Milk Industry Co. Ltd., Zama, Kanagawa 252-8583, Japan.ORCID 0000-0001-6019-9240
Hiroyuki YachiFaculty of Bioresources and Environmental Sciences, Ishikawa Prefectural University, Nonoichi, Ishikawa 921-8836, Japan.ORCID 0000-0002-3313-0704
Yuta SugiyamaFaculty of Bioresources and Environmental Sciences, Ishikawa Prefectural University, Nonoichi, Ishikawa 921-8836, Japan.
Shin KuriharaFaculty of Bioresources and Environmental Sciences, Ishikawa Prefectural University, Nonoichi, Ishikawa 921-8836, Japan.ORCID 0000-0002-2756-4629
Junko HiroseSchool of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga 522-8533, Japan.ORCID 0000-0001-6681-6908
Tadasu UrashimaDepartment of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan.
Jin-Zhong XiaoNext Generation Science Institute, Morinaga Milk Industry Co. Ltd., Zama, Kanagawa 252-8583, Japan.ORCID 0000-0002-8512-9086
Motomitsu KitaokaFood Research Institute, National Agriculture and Food Research Organization, Tsukuba, Ibaraki 305-8642, Japan.ORCID 0000-0002-0083-1838
Satoru FukiyaResearch Faculty of Agriculture, Hokkaido University, Sapporo, Hokkaido 060-8589, Japan.ORCID 0000-0002-3147-1070
Atsushi YokotaResearch Faculty of Agriculture, Hokkaido University, Sapporo, Hokkaido 060-8589, Japan.
Leila Lo LeggioDepartment of Chemistry, University of Copenhagen, Copenhagen 2100, Denmark.ORCID 0000-0002-5135-0882
Maher Abou HachemDepartment of Biotechnology and Bioengineering, Technical University of Denmark, Søltofts Plads, DK-2800 Kgs. Lyngby, Denmark.ORCID 0000-0001-8250-1842
Takane KatayamaFaculty of Bioresources and Environmental Sciences, Ishikawa Prefectural University, Nonoichi, Ishikawa 921-8836, Japan.ORCID 0000-0003-4009-7874
Ishikawa Prefectural University · JPMorinaga (Japan) · JPHokkaido University · JPKyoto University · JPTechnical University of Denmark · DKNational Agriculture and Food Research Organization · JPObihiro University of Agriculture and Veterinary Medicine · JPUniversity of Copenhagen · DKUniversity of Shiga Prefecture · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human gut microbiota established during infancy has persistent effects on health. In vitro studies have suggested that human milk oligosaccharides (HMOs) in breast milk promote the formation of a bifidobacteria-rich microbiota in infant guts; however, the underlying molecular mechanism remains elusive. Here, we characterized two functionally distinct but overlapping fucosyllactose transporters (FL transporter-1 and -2) from

Indexed as

AdultAgedBifidobacteriumBiological EvolutionFecesFemaleGastrointestinal MicrobiomeHumansInfantInfant, NewbornMaleMetagenomeMiddle AgedMilk, HumanOligosaccharidesSymbiosis2'-fucosyllactose3'-fucosyllactoseOligosaccharidesTrisaccharides

Identifiers

PMID31489370
PMCPMC6713505
OpenAlexW2971114933

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.